13-顺式视黄酸对二丁基亚硝胺诱导的小鼠膀胱尿路上皮多倍体变化的影响。
The effect of 13-cis-retinoic acid on dibutylnitrosamine induced polyploidy changes in mouse urothelium.
作者信息
Høstmark J, Farsund T
出版信息
Anticancer Res. 1982 May-Jun;2(3):145-50.
PMID:6289723
Abstract
The epithelium in the normal urinary bladder contains cells with diploid to octoploid DNA-content. The carcinogen dibutylnitrosamine (DBN), given subcutaneously in repeated doses causes a loss of polyploidy prior to cancer development. In this study the changes in polyploidy caused by DBN was followed by use of flow cytometry. 13-cis-retinoic acid did not prevent this loss of polyploidy, and did not affect the polyploidy in the normal urothelium.
摘要
正常膀胱的上皮含有DNA含量为二倍体至八倍体的细胞。致癌物质二丁基亚硝胺（DBN）经皮下反复给药，会在癌症发生之前导致多倍性丧失。在本研究中，通过流式细胞术追踪了DBN引起的多倍性变化。13-顺式维甲酸不能阻止这种多倍性丧失，且不影响正常尿路上皮的多倍性。
相似文献
1
The effect of 13-cis-retinoic acid on dibutylnitrosamine induced polyploidy changes in mouse urothelium.13-顺式视黄酸对二丁基亚硝胺诱导的小鼠膀胱尿路上皮多倍体变化的影响。
Anticancer Res. 1982 May-Jun;2(3):145-50.
2
Effects of 13-cis retinoic acid on dibutyl-nitrosamine-induced cell kinetic changes in mouse urinary bladder epithelium.13-顺式维甲酸对二丁基亚硝胺诱导的小鼠膀胱上皮细胞动力学变化的影响。
Anticancer Res. 1983 Sep-Oct;3(5):337-42.
3
Cell kinetics of mouse urinary bladder epithelium. V. Changes in the proportion of cells with various nuclear DNA content after repeated doses of cyclophosphamide.小鼠膀胱上皮细胞动力学。V. 重复给予环磷酰胺后不同核DNA含量细胞比例的变化。
Virchows Arch B Cell Pathol. 1978 Feb 14;26(4):369-73.
4
5
Cell kinetics of mouse urinary bladder epithelium. IV. Changes in cell proliferation, nuclear DNA content, and number of diploid, tetraploid and octoploid cells after a single dose of dibutylnitrosamine.
Virchows Arch B Cell Pathol. 1977 Nov 3;25(3):179-89.
6
7
Cell kinetics of mouse urinary bladder epithelium. VII. Changes in proliferation and nuclear DNA content after repeated doses of dibutylnitrosamine.
Virchows Arch B Cell Pathol. 1978 Mar 29;27(2):119-35.
8
9
Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid.
Cancer Res. 1977 Aug;37(8 Pt 2):2930-6.
10
Cystoscopy of chemically induced bladder neoplasms in rabbits administered the carcinogen dibutylnitrosamine.
Invest Urol. 1975 Jan;12(4):262-6.
Zotero 插件