Høostmark J, Farsund T
Anticancer Res. 1983 Sep-Oct;3(5):337-42.
The effect of 13-cis-retinoic acid on cell proliferation in normal urothelium and during early stages in N-nitrosodibutylamine (DBN) induced malignant transformation was studied in male hairless mice. The retinoic acid was administered orally, and the parameters studied were (a) variations in total cell number, (b) labelling index (LI), (c) mitotic rate (MR), (d) the proportions of DNA-synthesizing cells in the diploid and tetraploid fractions, and (e) morphological changes. 13-cis-retinoic acid caused no effect on these parameters in normal urothelium, nor did it prevent the changes caused by DBN in the urothelium prior to malignant development.
在雄性无毛小鼠中研究了13-顺式视黄酸对正常尿路上皮细胞增殖以及在N-亚硝基二丁胺（DBN）诱导的恶性转化早期阶段细胞增殖的影响。视黄酸经口服给药，所研究的参数包括：（a）总细胞数的变化；（b）标记指数（LI）；（c）有丝分裂率（MR）；（d）二倍体和四倍体部分中DNA合成细胞的比例；以及（e）形态学变化。13-顺式视黄酸对正常尿路上皮的这些参数没有影响，也不能阻止DBN在恶性发展之前引起的尿路上皮变化。
