β-内酰胺酶抑制剂CP-45,899与β-内酰胺类抗生素联合对多重耐药肠杆菌科细菌和假单胞菌属细菌的协同作用不一致。
Inconsistency of synergy between the beta-lactamase inhibitor CP-45,899 and beta-lactam antibiotics against multiply drug-resistant Enterobacteriaceae and pseudomonas species.
作者信息
Fass R J
出版信息
Antimicrob Agents Chemother. 1981 Feb;19(2):361-3. doi: 10.1128/AAC.19.2.361.
Abstract
Synergy between CP-45,899 and ampicillin or newer beta-lactam antibiotics against multiply drug-resistant Enterobacteriaceae and Pseudomonas species was inconsistent. In contrast, synergy between CP-45,899 and ampicillin against beta-lactamase-producing strains of Haemophilus influenzae type b and Bacteroides fragilis was consistent and marked.
摘要
CP-45899与氨苄西林或新型β-内酰胺类抗生素联合使用对抗多重耐药肠杆菌科细菌和假单胞菌属细菌时，协同作用并不一致。相比之下，CP-45899与氨苄西林联合使用对产β-内酰胺酶的b型流感嗜血杆菌菌株和脆弱拟杆菌的协同作用则是持续且显著的。
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Activity of beta-lactamase produced by Bacteroides fragilis against newly introduced cephalosporins.脆弱拟杆菌产生的β-内酰胺酶对新引入头孢菌素的活性。
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