舒巴坦联合氨苄西林对厌氧菌的体外疗效
In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria.
作者信息
Wexler H M, Harris B, Carter W T, Finegold S M
出版信息
Antimicrob Agents Chemother. 1985 May;27(5):876-8. doi: 10.1128/AAC.27.5.876.
Abstract
An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination of sulbactam and ampicillin was much more effective than ampicillin alone against Bacteroides fragilis strains but did not differ substantially from ampicillin alone against Fusobacterium spp., gram-positive rods, and gram-positive cocci.
摘要
将氨苄西林-舒巴坦组合与单独使用的氨苄西林、氯霉素、克林霉素和甲硝唑针对272株厌氧菌进行了比较。氯霉素和氨苄西林-舒巴坦最有效，在断点浓度（16微克/毫升）时可抑制98%至99%的测试菌株。舒巴坦和氨苄西林的组合对脆弱拟杆菌菌株的效果比单独使用氨苄西林要好得多，但与单独使用氨苄西林相比，对梭杆菌属、革兰氏阳性杆菌和革兰氏阳性球菌的效果没有显著差异。
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