脆弱拟杆菌对β-内酰胺类抗生素耐药的相关因素。
Factors contributing to resistance to beta-lactam antibiotics in Bacteroides fragilis.
作者信息
Olsson B, Dornbusch K, Nord C E
出版信息
Antimicrob Agents Chemother. 1979 Feb;15(2):263-8. doi: 10.1128/AAC.15.2.263.
Abstract
Fifteen strains of Bacteroides fragilis, five highly resistant, five moderately resistant, and five susceptible to benzylpenicillin and cephaloridine, were tested for beta-lactamase production. In the highly resistant and the moderately resistant groups of strains, a correlation between formation of beta-lactamase and minimal inhibitory concentrations was demonstrated. In the presence of the beta-lactamase inhibitors clavulanic acid and CP-45,899 at concentrations of 1 mug/ml, the susceptibility to cephaloridine increased fourfold or more in the beta-lactamase-producing strains. Crypticity measurements (beta-lactamase activity broken/intact cells) with cephaloridine as substrate could indicate a diffusion barrier in the cell wall.
摘要
对15株脆弱拟杆菌进行了β-内酰胺酶产生情况的检测，其中5株高度耐药，5株中度耐药，5株对苄青霉素和头孢菌素敏感。在高度耐药和中度耐药菌株组中，证实了β-内酰胺酶的形成与最低抑菌浓度之间存在相关性。在β-内酰胺酶抑制剂棒酸和CP-45,899浓度为1微克/毫升的情况下，产β-内酰胺酶的菌株对头孢菌素的敏感性提高了四倍或更多。以头孢菌素为底物的隐蔽性测量（β-内酰胺酶活性在破碎/完整细胞中的情况）可能表明细胞壁存在扩散屏障。
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