Maslow M J, Levine J F, Pollock A A, Simberkoff M S, Rahal J J
Antimicrob Agents Chemother. 1982 Jul;22(1):103-7. doi: 10.1128/AAC.22.1.103.
Eighteen patients with 21 serious infections were treated with ceftriaxone, 1 g intravenously every 12 h, for a mean duration of 8 days. Eighteen gram-negative and two gram-positive organisms were isolated. Sites of infection included blood (three patients), urinary tract (six patients), respiratory tract (seven patients), biliary tract (three patients), ascitic fluid (one patient), and skin (one patient). Serum, bile, and ascitic fluid concentrations of ceftriaxone were in excess of the minimal bactericidal concentration required for the infecting organism in all cases. A bacteriological response was demonstrated in 94% of the infections. A clinical response occurred in four infections from which no pathogens were recovered. In one patient, ceftriaxone failed to eradicate a peritoneal infection due to Bacteroides fragilis. In two patients, superinfection with enterococci developed both during and after therapy. Systemic tolerance to ceftriaxone was excellent.
18例患有21种严重感染的患者接受了头孢曲松治疗，静脉注射1克，每12小时一次，平均疗程为8天。分离出18株革兰氏阴性菌和2株革兰氏阳性菌。感染部位包括血液（3例患者）、泌尿道（6例患者）、呼吸道（7例患者）、胆道（3例患者）、腹水（1例患者）和皮肤（1例患者）。在所有病例中，头孢曲松的血清、胆汁和腹水浓度均超过感染病原体所需的最低杀菌浓度。94%的感染显示出细菌学反应。在4例未分离出病原体的感染中出现了临床反应。在1例患者中，头孢曲松未能根除脆弱拟杆菌引起的腹膜感染。在2例患者中，治疗期间和治疗后均发生了肠球菌二重感染。头孢曲松的全身耐受性良好。
