Totterdell B M, Nicholson K G, MacLeod J, Chrystie I L, Banatvala J E
J Med Virol. 1982;10(1):37-44. doi: 10.1002/jmv.1890100106.
Expressed breast milks (EBMs) were collected from mothers of rotavirus (RV)-excreting babies and from mothers whose babies were RV free during an outbreak of asymptomatic RV infection in a newborn nursery to determine the role of lacteal anti-RV neutralising activity, alpha1-anti-trypsin activity, and nonimmunoglobulin antiviral factor in protection of neonates from RV infection, and although all of the above factors were present in the majority of the EBMs, no correlation could be found between their presence in EBM and protection from RV infection. A significant rise in both neutralising activity and subgroup 2 antibodies, was demonstrated in the EBM of one mother who experienced a subgroup 2 RV-associated diarrhoea during lactation. However, the alpha1-anti-trypsin activity and the nonimmunoglobulin antiviral levels remained the same. The importance of these factors in passive immunity with reference to virus dose is discussed.
从轮状病毒（RV）排出婴儿的母亲以及新生儿托儿所无症状RV感染暴发期间其婴儿未感染RV的母亲那里收集了挤出的母乳（EBM），以确定乳汁中抗RV中和活性、α1-抗胰蛋白酶活性和非免疫球蛋白抗病毒因子在保护新生儿免受RV感染中的作用。尽管大多数EBM中都存在上述所有因素，但在EBM中这些因素的存在与预防RV感染之间未发现相关性。一位在哺乳期经历了2型RV相关性腹泻的母亲的EBM中，中和活性和2型抗体均显著升高。然而，α1-抗胰蛋白酶活性和非免疫球蛋白抗病毒水平保持不变。讨论了这些因素在针对病毒剂量的被动免疫中的重要性。
