从无症状新生儿感染中分离出的轮状病毒的遗传稳定性
Genetic stability of rotaviruses recovered from asymptomatic neonatal infections.
作者信息
Flores J, Sears J, Green K Y, Perez-Schael I, Morantes A, Daoud G, Gorziglia M, Hoshino Y, Chanock R M, Kapikian A Z
机构信息
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
J Virol. 1988 Dec;62(12):4778-81. doi: 10.1128/JVI.62.12.4778-4781.1988.
Abstract
The sequence of the VP7 gene from 19 rotavirus strains recovered from asymptomatically infected newborn infants was determined by direct analysis of transcript RNAs synthesized from virus present in the stool. For five viruses the entire VP7 gene was sequenced, whereas in the remaining instances only a portion of the gene could be sequenced. In 19 specimens collected over a 4-year period, only five nucleotide substitutions were detected. None of them resulted in an amino acid substitution. Examination of a 306-nucleotide segment of gene 4 in 11 specimens yielded similar results. These results suggest that the mutation rate of rotaviruses in nature is lower than that of single-stranded RNA viruses such as poliovirus and influenza virus.
摘要
通过直接分析从无症状感染的新生儿粪便中提取的病毒合成的转录RNA，确定了19株轮状病毒的VP7基因序列。对于5株病毒，对整个VP7基因进行了测序，而在其余情况下，只能对该基因的一部分进行测序。在4年期间收集的19个样本中，仅检测到5个核苷酸替换。它们均未导致氨基酸替换。对11个样本中基因4的306个核苷酸片段进行检测，得到了类似的结果。这些结果表明，自然环境中轮状病毒的突变率低于脊髓灰质炎病毒和流感病毒等单链RNA病毒。
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