Wheeler H
Neuropharmacology. 1982 Sep;21(9):941-4. doi: 10.1016/0028-3908(82)90089-2.
Electrical stimulation of the striatum in conscious rats elicits a contralateral head-turn. Modification of this response by opiate drugs injected sub-cutaneously or into the ipsilateral globus pallidus has been investigated. Morphine, normorphine and ethylketocyclazocine had no effect on the head-turn latency but met-enkephalin and D-Ala2, D-Leu5-enkephalin, injected into the pallidum, and smalL doses of etorphine injected subcutaneously, produced a dose-related slowing of the response. Large doses of the opiate receptor antagonist naloxone antagonised the effect of etorphine. These results suggest the presence of opiate delta receptors in the rat globus pallidus and this model may therefore prove useful for studying the effects of other agents acting at the delta receptor.
对清醒大鼠的纹状体进行电刺激会引发对侧转头。已经研究了皮下注射或注入同侧苍白球的阿片类药物对这种反应的影响。吗啡、去甲吗啡和乙基酮环唑辛对转头潜伏期没有影响，但注入苍白球的甲硫氨酸脑啡肽和D - Ala2，D - Leu5 - 脑啡肽，以及皮下注射小剂量的埃托啡，会使反应产生剂量相关的减慢。大剂量的阿片受体拮抗剂纳洛酮可拮抗埃托啡的作用。这些结果表明大鼠苍白球中存在阿片δ受体，因此该模型可能对研究作用于δ受体的其他药物的效果有用。
