Stone S S, Kemeny L J, Jensen M T
Vet Immunol Immunopathol. 1982 Sep;3(5):529-33. doi: 10.1016/0165-2427(82)90018-6.
Serum titers of virus-neutralizing (VN) antibody were 10 to 16 times higher in neonatal pigs than in young adult pigs, after single oral doses of virulent transmissible gastroenteritis virus (TGEV). To determine the reason for this higher response, sera from neonatal and young adult pigs, 18 to 21 days after exposure to TGEV, were collected and assayed for VN antibody by plaque reduction. In addition, sera of VN-positive and VN-negative neonatal pigs were analyzed for immunoglobulin classes by radial immunodiffusion technique. The competence of neonatal pigs to produce VN antibody with increased IgG levels was demonstrated. The higher antibody response seen in neonatal pigs, when compared to sera of young adult pigs, may be attributed to the increased replication of TGEV in the intestinal tracts of neonatal pigs or to the lack of other immunogens that may interfere or compete with the production of specific antibody.
单次口服强毒性传染性胃肠炎病毒（TGEV）后，新生仔猪的病毒中和（VN）抗体血清滴度比成年仔猪高10至16倍。为确定这种更高反应的原因，在新生仔猪和成年仔猪接触TGEV 18至21天后采集血清，通过蚀斑减少法检测VN抗体。此外，采用放射免疫扩散技术分析VN阳性和VN阴性新生仔猪血清的免疫球蛋白类别。结果表明新生仔猪产生VN抗体且IgG水平升高的能力。与成年仔猪血清相比，新生仔猪出现的更高抗体反应可能归因于TGEV在新生仔猪肠道中复制增加，或缺乏可能干扰或竞争特异性抗体产生的其他免疫原。
