Reh T, Kalil K
J Comp Neurol. 1982 Nov 1;211(3):276-83. doi: 10.1002/cne.902110306.
When pyramidal tract axons are severed in the infant hamster, the damaged fibers regrow via a new pathway to their normal terminal sites in the medulla and spinal cord and there form synaptic connections (Kalil and Reh, '79, '82). We studied the behavior of animals with infant and adult lesions of the medullary pyramid to determine the functional significance of the new pathway in maintaining normal motor behavior. Examination of behaviors normally mediated by the pyramidal tract, particularly the manipulation of sunflower seeds during feeding, revealed a correlation between the presence of the new tract and the preservation of function. Furthermore, in the adult animal with an infant lesion, the spared behaviors were lost when the new pathway was destroyed.
当幼仓鼠的锥体束轴突被切断时，受损纤维会通过一条新路径重新生长到它们在延髓和脊髓中的正常终末位点，并在那里形成突触连接（卡利尔和雷，1979年，1982年）。我们研究了患有延髓锥体幼年和成年损伤的动物的行为，以确定新路径在维持正常运动行为中的功能意义。对通常由锥体束介导的行为进行检查，特别是在进食过程中对葵花籽的操作，发现新束的存在与功能的保留之间存在相关性。此外，在患有幼年损伤的成年动物中，当新路径被破坏时，保留的行为就会丧失。
