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赭曲霉毒素和黄曲霉毒素对豚鼠血清蛋白、补体活性及抗布鲁氏菌抗体产生的影响。

Effect of ochratoxin and aflatoxin on serum proteins, complement activity, and antibody production to Brucella abortus in guinea pigs.

作者信息

Richard J L, Thurston J R, Deyoe B L, Booth G D

出版信息

Appl Microbiol. 1975 Jan;29(1):27-9. doi: 10.1128/am.29.1.27-29.1975.

Abstract

The effect of ochratoxin alone and in combination with aflatoxin and Brucella abortus antigen on complement activity, serum proteins, and antibody response in guinea pigs was investigated. Ochratoxin did not affect complement activity or antibody response and there was no interaction between ochratoxin and aflatoxin on any of the responses tested. Ochratoxin significantly lowered the level of beta-globulin in serum of guinea pigs. There was no significant interaction between aflatoxin and antigen on lowering of the serum albumin levels of guinea pigs.

摘要

研究了单独的赭曲霉毒素以及它与黄曲霉毒素和流产布鲁氏菌抗原联合使用对豚鼠补体活性、血清蛋白和抗体反应的影响。赭曲霉毒素不影响补体活性或抗体反应,并且在任何测试反应中,赭曲霉毒素和黄曲霉毒素之间均无相互作用。赭曲霉毒素显著降低了豚鼠血清中β-球蛋白的水平。在降低豚鼠血清白蛋白水平方面,黄曲霉毒素和抗原之间没有显著的相互作用。

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Effect of aflatoxin on complement activity in guinea pigs.
Proc Soc Exp Biol Med. 1972 Jan;139(1):300-3. doi: 10.3181/00379727-139-36130.
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Ochratoxicosis in Beagle dogs. II. Pathology.比格犬的赭曲霉毒素中毒。II. 病理学
Vet Pathol. 1973;10(3):219-31. doi: 10.1177/030098587301000304.
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Metabolism as a factor in determining the toxic action of the aflatoxins in different animal species.
Food Cosmet Toxicol. 1973 Apr;11(2):287-94. doi: 10.1016/s0015-6264(73)80496-1.

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