Snead O C, Bearden L J
Neuropharmacology. 1982 Nov;21(11):1137-44. doi: 10.1016/0028-3908(82)90171-x.
The present authors gave mu, delta, kappa, epsilon and sigma opiate receptor agonists intracerebroventricularly to rats both singly and in combination while monitoring the electroencephalogram from cortical and depth electrodes. Dose-response curves were plotted with naloxone against the changes produced by each agonist, and the effect of a number of anticonvulsant drugs on agonist-induced seizures was ascertained. Each opiate agonist produced a different seizure pattern with a different naloxone dose-response curve and anticonvulsant profile. The order of convulsive potency was epsilon greater than delta greater than mu greater than sigma much greater than kappa. Petit mal-like seizure activity was unique to the delta agonist, leucine-enkephalin, while only the mu agonist, morphine produced generalized convulsive seizures. These experiments raise the possibility that opiate systems in the brain may be involved in the pathogenesis of a wide spectrum of seizure disorders.
本研究作者向大鼠脑室内单独或联合给予μ、δ、κ、ε和σ阿片受体激动剂，同时通过皮层电极和深部电极监测脑电图。绘制了纳洛酮针对每种激动剂产生的变化的剂量反应曲线，并确定了多种抗惊厥药物对激动剂诱发癫痫发作的影响。每种阿片激动剂产生不同的癫痫发作模式，具有不同的纳洛酮剂量反应曲线和抗惊厥谱。惊厥效力顺序为ε＞δ＞μ＞σ＞＞κ。小发作样癫痫活动是δ激动剂亮氨酸脑啡肽所特有的，而只有μ激动剂吗啡会产生全身性惊厥发作。这些实验增加了大脑中的阿片系统可能参与多种癫痫疾病发病机制的可能性。
