Jones R N, Barry A L, Thornsberry C
Rev Infect Dis. 1982 Sep-Oct;4 Suppl:S366-73. doi: 10.1093/clinids/4.supplement_2.s366.
The level of antimicrobial activity of 3-desacetylcefotaxime was found to be approximately eightfold lower than that of cefotaxime. Variation in the inhibitory effects of desacetylcefotaxime was species dependent. Desacetylcefotaxime was 1-2 log2 dilutions more active than cefotaxime against Pseudomonas acidovorans and Pseudomonas cepacia. Desacetylcefotaxime and cefotaxime were bactericidal, and their minimal inhibitory concentrations were influenced only slightly by increases in the inoculum concentration. Synergy (complete and partial) of 75.8% was noted with the combination. Only with strains of Morganella morganii was the combination antagonistic, but these results were not clinically significant; i.e., all strains remained susceptible to cefotaxime.
研究发现，3-去乙酰头孢噻肟的抗菌活性水平比头孢噻肟低约八倍。去乙酰头孢噻肟抑制作用的变化因菌种而异。去乙酰头孢噻肟对食酸假单胞菌和洋葱伯克霍尔德菌的活性比对头孢噻肟高1-2个对数2稀释度。去乙酰头孢噻肟和头孢噻肟具有杀菌作用，其最低抑菌浓度仅受接种物浓度增加的轻微影响。联合用药时观察到75.8%的协同作用（完全协同和部分协同）。仅摩根氏摩根菌菌株的联合用药具有拮抗作用，但这些结果在临床上并不显著；即所有菌株对头孢噻肟仍敏感。
