阿米卡星联合用药对中度敏感于第三代头孢菌素的肠杆菌科细菌的抗菌活性。
Antimicrobial activity of amikacin combinations against Enterobacteriaceae moderately susceptible to third-generation cephalosporins.
作者信息
Jones R N, Packer R R
出版信息
Antimicrob Agents Chemother. 1982 Dec;22(6):985-9. doi: 10.1128/AAC.22.6.985.
Abstract
Enterobacteriaceae strains having elevated minimal inhibitory concentrations (greater than or equal to 2.0 to less than or equal to 32 micrograms/ml) of cefoperazone, cefotaxime, ceftazidime, and moxalactam were synergistically inhibited by amikacin combinations (54.1 to 69.6% occurrence). Indifference was rare (8.1% for moxalactam), and true antagonistic interactions were not observed. Strains resistant or susceptible to these new cephalosporins were also synergistically inhibited by the addition of amikacin, reducing resistant cephalosporin minimal inhibitory concentrations to clinically achievable levels.
摘要
对头孢哌酮、头孢噻肟、头孢他啶和拉氧头孢的最低抑菌浓度升高（大于或等于2.0至小于或等于32微克/毫升）的肠杆菌科菌株，被阿米卡星联合用药协同抑制（发生率为54.1%至69.6%）。无协同作用的情况很少见（拉氧头孢为8.1%），且未观察到真正的拮抗相互作用。对这些新型头孢菌素耐药或敏感的菌株，加入阿米卡星后也被协同抑制，将耐药头孢菌素的最低抑菌浓度降低至临床可达到的水平。
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