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1
Antimicrobial activity of amikacin combinations against Enterobacteriaceae moderately susceptible to third-generation cephalosporins.阿米卡星联合用药对中度敏感于第三代头孢菌素的肠杆菌科细菌的抗菌活性。
Antimicrob Agents Chemother. 1982 Dec;22(6):985-9. doi: 10.1128/AAC.22.6.985.
2
Aminoglycosides plus beta-lactams against gram-negative organisms. Evaluation of in vitro synergy and chemical interactions.氨基糖苷类药物与β-内酰胺类药物联合用于抗革兰氏阴性菌。体外协同作用及化学相互作用的评估。
Am J Med. 1986 Jun 30;80(6B):126-37. doi: 10.1016/0002-9343(86)90490-0.
3
Enhanced in vitro bactericidal activity of amikacin or gentamicin combined with three new extended-spectrum cephalosporins against cephalothin-resistant members of the family Enterobacteriaceae.阿米卡星或庆大霉素与三种新型广谱头孢菌素联合使用对耐头孢噻吩肠杆菌科细菌的体外杀菌活性增强。
Antimicrob Agents Chemother. 1984 Jun;25(6):725-8. doi: 10.1128/AAC.25.6.725.
4
[In vitro study of combinations between third-generation cephalosporins and aminoglycosides on Enterobacteriaceae].第三代头孢菌素与氨基糖苷类药物联用对肠杆菌科细菌的体外研究
Pathol Biol (Paris). 1983 Jun;31(6):483-7.
5
Interaction of third generation cephalosporins combined with amikacin against Pseudomonas aeruginosa.
Bol Asoc Med P R. 1985 Jun;77(6):242-4.
6
Early synergistic interactions between amikacin and six beta-lactam antibiotics against multiply resistant members of the family Enterobacteriaceae.阿米卡星与六种β-内酰胺类抗生素对多重耐药肠杆菌科细菌的早期协同相互作用。
Antimicrob Agents Chemother. 1984 Sep;26(3):378-81. doi: 10.1128/AAC.26.3.378.
7
Combination effect of cefmenoxime with four aminoglycosides on Enterobacteriaceae susceptible and moderately susceptible to this new cephalosporin.
Zentralbl Bakteriol Mikrobiol Hyg A. 1984 Aug;257(3):383-7.
8
In vitro activity of newer beta-lactam agents in combination with amikacin against Pseudomonas aeruginosa, Klebsiella pneumoniae, and Serratia marcescens.新型β-内酰胺类药物与阿米卡星联合对铜绿假单胞菌、肺炎克雷伯菌和粘质沙雷菌的体外活性
Diagn Microbiol Infect Dis. 1983 Dec;1(4):287-93. doi: 10.1016/0732-8893(83)90004-4.
9
In vitro activities of cefepime alone and with amikacin against aminoglycoside-resistant gram-negative bacteria.头孢吡肟单独及与阿米卡星联合对氨基糖苷类耐药革兰阴性菌的体外活性。
Antimicrob Agents Chemother. 1991 Dec;35(12):2652-4. doi: 10.1128/AAC.35.12.2652.
10
Antimicrobial activity of cefotiam combinations against Enterobacteriaceae moderately susceptible or resistant to this new cephalosporin.头孢替安联合用药对中度敏感或对这种新型头孢菌素耐药的肠杆菌科细菌的抗菌活性。
Drugs Exp Clin Res. 1986;12(4):325-7.

引用本文的文献

1
Early synergistic interactions between amikacin and six beta-lactam antibiotics against multiply resistant members of the family Enterobacteriaceae.阿米卡星与六种β-内酰胺类抗生素对多重耐药肠杆菌科细菌的早期协同相互作用。
Antimicrob Agents Chemother. 1984 Sep;26(3):378-81. doi: 10.1128/AAC.26.3.378.
2
In vitro synergistic activities of aminoglycosides and new beta-lactams against multiresistant Pseudomonas aeruginosa.氨基糖苷类药物与新型β-内酰胺类药物对多重耐药铜绿假单胞菌的体外协同活性
Antimicrob Agents Chemother. 1984 Apr;25(4):534-6. doi: 10.1128/AAC.25.4.534.
3
Moxalactam (latamoxef). A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.拉氧头孢。对其抗菌活性、药代动力学特性及治疗用途的综述。
Drugs. 1983 Oct;26(4):279-333. doi: 10.2165/00003495-198326040-00001.
4
In vitro and in vivo synergy between ceftriaxone and aminoglycosides against Pseudomonas aeruginosa.头孢曲松与氨基糖苷类药物对铜绿假单胞菌的体外及体内协同作用。
Eur J Clin Microbiol. 1983 Oct;2(5):489-95. doi: 10.1007/BF02013914.
5
High performance liquid chromatographic determination of moxalactam in human plasma and cerebrospinal fluid.高效液相色谱法测定人血浆和脑脊液中拉氧头孢的含量。
Eur J Clin Pharmacol. 1985;29(2):225-9. doi: 10.1007/BF00547427.
6
Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.头孢他啶。对其抗菌活性、药代动力学特性及治疗用途的综述。
Drugs. 1985 Feb;29(2):105-61. doi: 10.2165/00003495-198529020-00002.
7
Antimicrobial activity of ceftriaxone, cefotaxime, desacetylcefotaxime, and cefotaxime-desacetylcefotaxime in the presence of human serum.头孢曲松、头孢噻肟、去乙酰头孢噻肟及头孢噻肟-去乙酰头孢噻肟在人血清存在下的抗菌活性。
Antimicrob Agents Chemother. 1987 May;31(5):818-20. doi: 10.1128/AAC.31.5.818.
8
In vitro antimicrobial spectrum, occurrence of synergy, and recommendations for dilution susceptibility testing concentrations of the cefoperazone-sulbactam combination.头孢哌酮-舒巴坦组合的体外抗菌谱、协同作用的发生情况以及稀释药敏试验浓度的建议。
J Clin Microbiol. 1987 Sep;25(9):1725-9. doi: 10.1128/jcm.25.9.1725-1729.1987.
9
In vitro activity of piperacillin, ticarcillin, and mezlocillin alone and in combination with aminoglycosides against Pseudomonas aeruginosa.哌拉西林、替卡西林和美洛西林单独及与氨基糖苷类联合应用对铜绿假单胞菌的体外活性。
Antimicrob Agents Chemother. 1986 Jul;30(1):25-30. doi: 10.1128/AAC.30.1.25.
10
Antibiotic combinations: should they be tested?抗生素联合使用：是否应该进行检测？
Clin Microbiol Rev. 1988 Apr;1(2):139-56. doi: 10.1128/CMR.1.2.139.

本文引用的文献

1
Method of reliable determination of minimal lethal antibiotic concentrations.可靠测定最低致死抗生素浓度的方法。
Antimicrob Agents Chemother. 1980 Nov;18(5):699-708. doi: 10.1128/AAC.18.5.699.
2
Transferable multiple antibiotic resistance in Haemophilus influenzae.流感嗜血杆菌中的可转移多重抗生素耐药性。
J Antimicrob Chemother. 1981 Sep;8(3):187-92. doi: 10.1093/jac/8.3.187.
3
Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism.阴沟肠杆菌和铜绿假单胞菌中的头孢菌素酶截留不可水解头孢菌素作为一种可能的耐药机制。
Antimicrob Agents Chemother. 1982 May;21(5):711-7. doi: 10.1128/AAC.21.5.711.
4
Comparative in vitro synergistic activity of new beta-lactam antimicrobial agents and amikacin against Pseudomonas aeruginosa and Serratia marcescens.新型β-内酰胺类抗菌剂与阿米卡星对铜绿假单胞菌和粘质沙雷氏菌的体外协同活性比较
Antimicrob Agents Chemother. 1981 Aug;20(2):239-43. doi: 10.1128/AAC.20.2.239.
5
Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.莫西拉酸（LY127935），一种新型半合成1-氧杂-β-内酰胺抗生素，具有显著的抗菌活性：与头孢孟多和妥布霉素的体外比较。
Antimicrob Agents Chemother. 1980 Apr;17(4):750-6. doi: 10.1128/AAC.17.4.750.
6
Cefoperazone (T-1551), a new semisynthetic cephalosporin: comparison with cephalothin and gentamicin.头孢哌酮（T - 1551），一种新型半合成头孢菌素：与头孢噻吩和庆大霉素的比较。
Antimicrob Agents Chemother. 1980 Apr;17(4):743-9. doi: 10.1128/AAC.17.4.743.
7
Antimicrobial activity of desacetylcefotaxime alone and in combination with cefotaxime: evidence of synergy.去乙酰头孢噻肟单独及与头孢噻肟联合应用的抗菌活性：协同作用证据
Rev Infect Dis. 1982 Sep-Oct;4 Suppl:S366-73. doi: 10.1093/clinids/4.supplement_2.s366.
8
Comparative synergistic activity of cefoperazone, cefotaxime, moxalactam, and carbenicillin, combined with tobramycin, against Pseudomonas aeruginosa.头孢哌酮、头孢噻肟、拉氧头孢和羧苄西林与妥布霉素联合应用对铜绿假单胞菌的比较协同活性。
Antimicrob Agents Chemother. 1981 Feb;19(2):332-4. doi: 10.1128/AAC.19.2.332.
9
Synergistic activity of cefoperazone in combination with beta-lactamase inhibitors.头孢哌酮与β-内酰胺酶抑制剂联合应用的协同活性。
J Antimicrob Chemother. 1981 Mar;7(3):287-92. doi: 10.1093/jac/7.3.287.
10
Cefotaxime: in vitro activity and tentative interpretive standards for disk susceptibility testing.头孢噻肟：体外活性及纸片药敏试验的初步解释标准
Antimicrob Agents Chemother. 1980 Jul;18(1):88-93. doi: 10.1128/AAC.18.1.88.

阿米卡星联合用药对中度敏感于第三代头孢菌素的肠杆菌科细菌的抗菌活性。

Antimicrobial activity of amikacin combinations against Enterobacteriaceae moderately susceptible to third-generation cephalosporins.

作者信息

Jones R N, Packer R R

出版信息

Antimicrob Agents Chemother. 1982 Dec;22(6):985-9. doi: 10.1128/AAC.22.6.985.

DOI:10.1128/AAC.22.6.985
PMID:7159071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185706/
Abstract

Enterobacteriaceae strains having elevated minimal inhibitory concentrations (greater than or equal to 2.0 to less than or equal to 32 micrograms/ml) of cefoperazone, cefotaxime, ceftazidime, and moxalactam were synergistically inhibited by amikacin combinations (54.1 to 69.6% occurrence). Indifference was rare (8.1% for moxalactam), and true antagonistic interactions were not observed. Strains resistant or susceptible to these new cephalosporins were also synergistically inhibited by the addition of amikacin, reducing resistant cephalosporin minimal inhibitory concentrations to clinically achievable levels.

摘要

对头孢哌酮、头孢噻肟、头孢他啶和拉氧头孢的最低抑菌浓度升高（大于或等于2.0至小于或等于32微克/毫升）的肠杆菌科菌株，被阿米卡星联合用药协同抑制（发生率为54.1%至69.6%）。无协同作用的情况很少见（拉氧头孢为8.1%），且未观察到真正的拮抗相互作用。对这些新型头孢菌素耐药或敏感的菌株，加入阿米卡星后也被协同抑制，将耐药头孢菌素的最低抑菌浓度降低至临床可达到的水平。