Schuyler M R, Thigpen T P, Salvaggio J E
Ann Intern Med. 1978 Mar;88(3):355-8. doi: 10.7326/0003-4819-88-3-355.
We studied pulmonary and systemic aspects of the immune response in a patient with pigeon breeder's disease before and after an inhalation challenge with pigeon serum. Macrophage migration inhibition was induced with bronchoalveolar wash cells exposed to both pigeon serum and pigeon dropping extract before but not after challenge. Peripheral blood lymphocytes exposed to these antigens did not induce inhibition of guinea pig peritoneal macrophage migration before challenge. However, after challenge peripheral blood lymphocytes did cause macrophage migration inhibition when exposed to pigeon serum. Both systemic and bronchoalveolar lymphocytes proliferated when exposed to these pigeon antigens in vitro. Our patient represents the first reported case of lymphokine production by pulmonary as well as systemic lymphocytes in hypersensitivity pneumonitis.
我们研究了一位鸽饲养者病患者在吸入鸽血清激发前后免疫反应的肺部和全身情况。在激发前，支气管肺泡灌洗细胞暴露于鸽血清和鸽粪提取物时可诱导巨噬细胞移动抑制，而激发后则无此现象。在激发前，外周血淋巴细胞暴露于这些抗原时不会诱导豚鼠腹腔巨噬细胞移动抑制。然而，激发后，外周血淋巴细胞暴露于鸽血清时确实会导致巨噬细胞移动抑制。当体外暴露于这些鸽抗原时，全身和支气管肺泡淋巴细胞都会增殖。我们的患者是首例报道的在过敏性肺炎中肺部和全身淋巴细胞产生淋巴因子的病例。
