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[氯化锂对大鼠乙醇偏好性发展的预防作用]

[Preventive effect of lithium chloride on the development in rats of a preference for ethanol].

作者信息

Zakusov V V, Liubimov B I, Iavorskiĭ A N, Fokin V I

出版信息

Biull Eksp Biol Med. 1978 Jan;85(1):33-6.

PMID:564216
Abstract

It was revealed in experiments on rats treated with a 5% ethanol solution with equal quantities of LiCl (experiment) and NaCl (control) for seven weeks as the only source of liquid that with li+ concentration in the blood plasma of approximately 0.6 meq/1 LiCl prevented the development of alcohol dependence. On studying the neurosecretory hypothalamic nuclei, hypophysis and adrenal cortex of the same animals a certain correlation has been demonstrated between the morphofunctional condition of the mentioned formations, the degree of ethanol preference development and the character of LiCl influence on the process.

摘要

在用等量的LiCl(实验组)和NaCl(对照组)的5%乙醇溶液作为唯一液体来源对大鼠进行为期七周的实验中发现,当血浆中Li⁺浓度约为0.6 meq/1时,LiCl可防止酒精依赖的发展。在研究同一动物的神经分泌下丘脑核、垂体和肾上腺皮质时,已证明上述结构的形态功能状况、乙醇偏好发展程度与LiCl对该过程的影响特征之间存在一定的相关性。

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1
[Preventive effect of lithium chloride on the development in rats of a preference for ethanol].[氯化锂对大鼠乙醇偏好性发展的预防作用]
Biull Eksp Biol Med. 1978 Jan;85(1):33-6.
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[Effect of lithium chloride on ethanol uptake by rats].[氯化锂对大鼠乙醇摄取的影响]
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[Monoamines and peptidergic Gomori-positive neurosecretory cells of the paraventricular nucleus of the rat hypothalamus in chronic alcohol consumption].[长期饮酒大鼠下丘脑室旁核中的单胺能和肽能Gomori阳性神经分泌细胞]
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[Effect of lithium chloride on the rat hypothalamus neurosecretory system].[氯化锂对大鼠下丘脑神经分泌系统的影响]
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