酮康唑及其脱酰基衍生物对恶性疟原虫和念珠菌分离株的活性。
Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates.
作者信息
Pfaller M A, Segal J J, Krogstad D J
出版信息
Antimicrob Agents Chemother. 1982 Nov;22(5):917-9. doi: 10.1128/AAC.22.5.917.
Abstract
Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole, based on [(3)H]hypoxanthine uptake and quantitative parasite counts. In contrast, there were no significant differences between these drugs in their activity against clinical isolates of Candida spp.
摘要
基于[³H]次黄嘌呤摄取和寄生虫定量计数，去酰基酮康唑对恶性疟原虫的活性比酮康唑高15至50倍。相比之下，这些药物对念珠菌临床分离株的活性没有显著差异。
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