Thawerani H, Sanchez R L, Rosai J, Dorfman R F
Arch Dermatol. 1978 Feb;114(2):191-7.
Ten patients with sinus histiocytosis with massive lymphadenopathy (SHML) also had cutaneous involvement. Seven of the ten were children. The skin lesions were solitary in three patients and multiple in seven. They were papular or nodular, up to 4 cm in diameter, and often had a xanthomatous appearance. Microscopically, they were constituted by a dermal infiltrate made up predominantly of histiocytes, plasma cells, and lymphocytes. Some of the histiocytes contained phagocytosed lymphocytes in their cytoplasm. The microscopic differential diagnosis includes dermatofibroma, xanthoma, Tangier disease, histiocytosis X, reticulohistiocytoma, juvenile xanthogranuloma, and leprosy.
十例伴有巨大淋巴结病的窦性组织细胞增生症（SHML）患者也有皮肤受累。十例中有七例为儿童。三名患者的皮肤损害为单发，七名患者为多发。损害为丘疹或结节，直径达4厘米，常呈黄色瘤样外观。显微镜下，它们由主要由组织细胞、浆细胞和淋巴细胞组成的真皮浸润构成。一些组织细胞的胞质内含有吞噬的淋巴细胞。显微镜下鉴别诊断包括皮肤纤维瘤、黄瘤、Tangier病、组织细胞增多症X、网状组织细胞瘤、幼年性黄色肉芽肿和麻风。
