Schmid M B, Roth J R
J Bacteriol. 1983 Feb;153(2):1114-9. doi: 10.1128/jb.153.2.1114-1119.1983.
Two internal promoters in the his operon of Salmonella typhimurium have been precisely mapped genetically. The internal promoters are found in, or very close to, gene border regions in the his operon. The his operon was examined for the presence of additional internal promoters whose transcripts were sensitive to rho-mediated transcription termination and therefore had escaped detection. No new internal promoters were found. It is argued that the internal promoters described here are not likely to be fortuitous message start sites, but may play a physiologically important role in operon expression.
鼠伤寒沙门氏菌组氨酸操纵子中的两个内部启动子已通过遗传学方法精确绘制图谱。内部启动子位于组氨酸操纵子的基因边界区域内或非常靠近该区域。对组氨酸操纵子进行了检查,以寻找其他内部启动子,这些启动子的转录本对rho介导的转录终止敏感,因此此前未被检测到。未发现新的内部启动子。有人认为,这里描述的内部启动子不太可能是偶然的信息起始位点,而可能在操纵子表达中发挥重要的生理作用。