Chang G W, Roth J R, Ames B N
J Bacteriol. 1971 Oct;108(1):410-4. doi: 10.1128/jb.108.1.410-414.1971.
The hisT gene, one of six genes in which mutation causes derepression of the histidine operon in Salmonella typhimurium, is shown to code for a protein that is not essential for the growth of the bacteria. This is indicated by the characterization of particular classes of mutations in the hisT gene: amber mutations, frame-shift mutations, and temperature-sensitive mutations that affect repression but not growth. In addition, the class of semilethal mutations was selected for but not found.
hisT基因是鼠伤寒沙门氏菌中六个因突变导致组氨酸操纵子去阻遏的基因之一，已证明它编码一种对细菌生长并非必需的蛋白质。这一点通过对hisT基因中特定类型突变的特征分析得以表明：琥珀突变、移码突变以及影响阻遏但不影响生长的温度敏感突变。此外，选择了半致死突变类型，但未发现此类突变。
