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大鼠脾脏中非淋巴细胞的特征，特别提及T细胞区域中强Ia阳性分支细胞。

Characterization of nonlymphoid cells in rat spleen, with special reference to strongly Ia-positive branched cells in T-cell areas.

作者信息

Dijkstra C D

出版信息

J Reticuloendothel Soc. 1982 Sep;32(3):167-78.

PMID:6296385
Abstract

By use of a monoclonal antibody against Ia antigen in an immunoperoxidase method, strongly Ia-positive branched cells are found in the T-cell areas of the splenic white pulp of the rat. In order to further characterize these cells, enzyme histochemical characteristics, phagocytic capacity, and irradiation sensitivity have been studied. Evidence is presented that these strongly Ia-positive branched cells represent interdigitating cells. The influence of whole-body irradiation on interdigitating cells is discussed. Comparison with data from the literature on the in vitro dendritic cell isolated from spleen cell suspensions reveals many similarities between the described interdigitating cell in vivo and the dendritic cell in vitro.

摘要

通过免疫过氧化物酶法使用抗Ia抗原的单克隆抗体，在大鼠脾脏白髓的T细胞区域发现了强Ia阳性的分支细胞。为了进一步表征这些细胞，研究了酶组织化学特征、吞噬能力和辐射敏感性。有证据表明这些强Ia阳性的分支细胞代表交错突细胞。讨论了全身照射对交错突细胞的影响。与文献中从脾细胞悬液中分离出的体外树突状细胞的数据进行比较，发现所描述的体内交错突细胞与体外树突状细胞有许多相似之处。

相似文献

1
Characterization of nonlymphoid cells in rat spleen, with special reference to strongly Ia-positive branched cells in T-cell areas.大鼠脾脏中非淋巴细胞的特征，特别提及T细胞区域中强Ia阳性分支细胞。
J Reticuloendothel Soc. 1982 Sep;32(3):167-78.
2
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Immunology. 1981 Dec;44(4):727-36.
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Ontogeny of non-lymphoid and lymphoid cells in the rat gut with special reference to large mononuclear Ia-positive dendritic cells.大鼠肠道中非淋巴细胞和淋巴细胞的个体发生，特别提及大单核Ia阳性树突状细胞。
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Dendritic cells and resting B cells form clusters in vitro and in vivo: T cell independence, partial LFA-1 dependence, and regulation by cross-linking surface molecules.树突状细胞与静息B细胞在体内外均可形成簇：T细胞非依赖性、部分LFA-1依赖性以及通过交联表面分子进行调节。
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引用本文的文献

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The endocytic activity of dendritic cells.树突状细胞的内吞活性。
J Exp Med. 1995 Aug 1;182(2):283-8. doi: 10.1084/jem.182.2.283.
2
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J Exp Med. 1994 Nov 1;180(5):1849-60. doi: 10.1084/jem.180.5.1849.
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Veiled cells in chronic idiopathic inflammatory bowel disease.慢性特发性炎症性肠病中的隐蔽细胞
Clin Exp Immunol. 1984 Feb;55(2):377-87.
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Ontogeny of non-lymphoid and lymphoid cells in the rat gut with special reference to large mononuclear Ia-positive dendritic cells.大鼠肠道中非淋巴细胞和淋巴细胞的个体发生，特别提及大单核Ia阳性树突状细胞。
Immunology. 1983 Oct;50(2):303-14.
5
Local cellular immune response in ascending urinary tract infection: occurrence of T-cells, immunoglobulin-producing cells, and Ia-expressing cells in rat urinary tract tissue.上行性尿路感染中的局部细胞免疫反应：大鼠尿路组织中T细胞、免疫球蛋白产生细胞和Ia表达细胞的出现情况
Infect Immun. 1984 Jun;44(3):627-32. doi: 10.1128/iai.44.3.627-632.1984.
6
Regeneration of splenic tissue after autologous subcutaneous implantation: homing of T- and B- and Ia-positive cells in the white pulp of the rat spleen.自体皮下植入后脾组织的再生：T细胞、B细胞和Ia阳性细胞在大鼠脾脏白髓中的归巢。
Cell Tissue Res. 1983;229(1):97-107. doi: 10.1007/BF00217883.
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Non-lymphoid cells of bronchus-associated lymphoid tissue of the rat in situ and in suspension. With special reference to interdigitating and follicular dendritic cells.大鼠支气管相关淋巴组织原位及悬浮状态下的非淋巴细胞。特别提及交错突细胞和滤泡树突状细胞。
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Immunology. 1985 May;55(1):23-30.