Wilders M M, Drexhage H A, Kokjé M, Verspaget H W, Meuwissen S G
Clin Exp Immunol. 1984 Feb;55(2):377-87.
The mononuclear cell system in the human gut wall of patients with Crohn's disease (CD), ulcerative colitis (UC) and normal controls was studied, with special reference to the so called antigen presenting veiled cells. These cells have already extensively been studied in the skin and are known as Langerhans' cells in the epidermis and dermis, veiled cells in the skin lymph and interdigitating cells in lymph nodes. Recently they were also found in gut associated lymphoid tissue, i.e. Peyer's patches of the rat. Here we describe the presence of similar cells in chronic idiopathic inflammatory bowel disease (CIBD). They resemble veiled cells in moving pattern, strong Ia positivity, no or only weak acid phosphatase activity, and ultrastructure. However, many of the described cells combine these characteristics with those of phagocytic macrophages. In the gut wall of controls veiled cells were virtually absent and phagocytic macrophages were almost exclusively recognized. These findings suggest that more intensive antigen handling takes place in the gut wall of CIBD patients than in normal gut. Clear cut associations with sex, age, duration or activity of disease were not observed in this limited study, and the exact significance of the presence of such cells needs further clarification.
对克罗恩病（CD）、溃疡性结肠炎（UC）患者及正常对照者的人肠壁单核细胞系统进行了研究，特别关注了所谓的抗原呈递面纱细胞。这些细胞已在皮肤中得到广泛研究，在表皮和真皮中被称为朗格汉斯细胞，在皮肤淋巴中为面纱细胞，在淋巴结中为交错突细胞。最近在肠道相关淋巴组织中也发现了它们，即大鼠的派尔集合淋巴结。在此我们描述了慢性特发性炎症性肠病（CIBD）中类似细胞的存在。它们在移动模式、强烈的Ia阳性、无或仅有微弱的酸性磷酸酶活性以及超微结构方面类似于面纱细胞。然而，许多所描述的细胞将这些特征与吞噬性巨噬细胞的特征相结合。在对照者的肠壁中几乎不存在面纱细胞，几乎只能识别出吞噬性巨噬细胞。这些发现表明，与正常肠道相比，CIBD患者的肠壁中发生了更强烈的抗原处理。在这项有限的研究中未观察到与性别、年龄、病程或疾病活动的明确关联，此类细胞存在的确切意义需要进一步阐明。
