与猿猴肉瘤病毒转化基因相对应的5'病毒和人类细胞序列。
5' viral and human cellular sequences corresponding to the transforming gene of simian sarcoma virus.
作者信息
Josephs S F, Dalla-Favera R, Gelmann E P, Gallo R C, Wong-Staal F
出版信息
Science. 1983 Feb 4;219(4584):503-5. doi: 10.1126/science.6297002.
PMID:6297002
Abstract
The 5' nucleotide sequences of the transforming gene of simian sarcoma virus (v-sis) and its human cellular homolog (c-sis) were compared. A short homology was found between helper virus and cellular DNA sequences at the junction of v-sis and c-sis, which may have had a role in the original recombination event leading to the generation of simian sarcoma virus.
摘要
对猿猴肉瘤病毒（v-sis）的转化基因及其人类细胞同源物（c-sis）的5'核苷酸序列进行了比较。在v-sis和c-sis交界处的辅助病毒与细胞DNA序列之间发现了一段短同源性，这可能在导致猿猴肉瘤病毒产生的原始重组事件中发挥了作用。
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