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v-myc基因发生突变的禽骨髓细胞瘤病毒（MC29）的致病性改变

Altered pathogenicity of avian myelocytomatosis (MC29) viruses with mutations in the v-myc gene.

作者信息

Enrietto P J, Hayman M J, Ramsay G M, Wyke J A, Payne L N

出版信息

Virology. 1983 Jan 15;124(1):164-72. doi: 10.1016/0042-6822(83)90300-8.

DOI:10.1016/0042-6822(83)90300-8
PMID:6297150
Abstract

Avian myelocytomatosis virus MC29 inoculated into the wing web of 1-day-old Brown Leghorn chickens causes a high incidence of tumors, predominantly endotheliomas that are apparently induced directly by the action of the viral myc gene. Mutants of MC29, in which portions of the v-myc gene have been deleted and which have reduced ability to transform macrophages in vitro, induce few tumors, among which lymphomas and osteopetrosis predominate. Analysis of lymphomas from birds infected with mutant MC29 suggested that they were a result of helper virus action rather than the mutant MC29.

摘要

将禽骨髓细胞瘤病毒MC29接种到1日龄的白来航鸡翼蹼中会导致高肿瘤发生率，主要是内皮瘤，显然是由病毒myc基因的作用直接诱导产生的。MC29的突变体，其中部分v-myc基因已被删除，并且在体外转化巨噬细胞的能力降低，诱导产生的肿瘤很少，其中淋巴瘤和骨质石化占主导。对感染突变体MC29的鸟类的淋巴瘤分析表明，它们是辅助病毒作用的结果，而不是突变体MC29的作用。

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引用本文的文献

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Vet Res Commun. 1996;20(1):83-108. doi: 10.1007/BF00346580.
2
Quail embryo fibroblasts transformed by four v-myc-containing virus isolates show enhanced proliferation but are non tumorigenic.由四种含v-myc的病毒分离株转化的鹌鹑胚胎成纤维细胞显示出增殖增强，但无致瘤性。
EMBO J. 1983;2(12):2385-9. doi: 10.1002/j.1460-2075.1983.tb01750.x.
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MC29 deletion mutants which fail to transform chicken macrophages are competent for transformation of quail macrophages.
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J Virol. 1987 Jul;61(7):2138-42. doi: 10.1128/JVI.61.7.2138-2142.1987.
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J Virol. 1986 Oct;60(1):167-76. doi: 10.1128/JVI.60.1.167-176.1986.
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