Wittmann G, Ohlinger V, Rziha H J
Arch Virol. 1983;75(1-2):29-41. doi: 10.1007/BF01314125.
Pigs which were vaccinated with an inactivated ADV vaccine developed a latent ADV infection up to 18 months after ADV challenge. Up to 6.5 months p.i. latent virus could be demonstrated by co-cultivation of different organ tissues (lungs, tonsils, olfactory bulb, brain stem, medulla). Afterwards, reactivation of latent virus was only achieved by immunosuppression of the animals. Immunosuppression led to a limited virus replication in nasal mucosa, tonsils, lymph nodes and central nervous system. In addition ADV was detected in the nasal secretions., Humoral and cellular immunity was investigated before and after immunosuppression of the animals. Before immunosuppression most of the animals displayed SCC, ADV-ADCC and ADV-LYST, and all animals had medium to high titres of neutralizing serum antibodies. After immunosuppression the number of pigs reacting in SCC and ADV-LYST, assays was distinctly reduced, but the number of animals reacting in ADV-ADCC assays remained unaltered. A significant reduction of serum antibody titres occurred only in 2 of 12 animals one day after the end of immunosuppression.
用灭活的腺病毒疫苗接种的猪在腺病毒攻击后长达18个月会发生潜伏性腺病毒感染。感染后长达6.5个月，通过不同器官组织（肺、扁桃体、嗅球、脑干、延髓）的共培养可证明潜伏病毒的存在。之后，潜伏病毒的重新激活仅通过对动物进行免疫抑制来实现。免疫抑制导致病毒在鼻粘膜、扁桃体、淋巴结和中枢神经系统中有限复制。此外，在鼻分泌物中检测到腺病毒。在对动物进行免疫抑制前后研究了体液免疫和细胞免疫。免疫抑制前，大多数动物表现出SCC、ADV-ADCC和ADV-LYST，并且所有动物都有中到高滴度的中和血清抗体。免疫抑制后，在SCC和ADV-LYST试验中产生反应的猪的数量明显减少，但在ADV-ADCC试验中产生反应的动物数量保持不变。仅在免疫抑制结束后一天，12只动物中有2只血清抗体滴度显著降低。
