Richardson J S, Zaleski W A
Biol Psychiatry. 1983 Jan;18(1):99-101. doi: 10.1016/0378-1097(83)90142-8.
A 15-year-old male with a long history of self-mutilation resembling the Lesch-Nyhan syndrome, but with normal uric acid levels, was treated with naloxone. Pain-inducing behavior decreased in the evenings following infusion of the drug, and was markedly reduced for 2 days following the treatment period. Though not recommended as therapy, the observations suggest that naloxone may play a role in the regulation of endorphin/enkephalin neural systems.
一名15岁男性，有长期自残史，症状类似莱施-奈恩综合征，但尿酸水平正常，接受了纳洛酮治疗。在输注该药物后的晚上，诱发疼痛的行为减少，在治疗期后的2天内明显减少。尽管不推荐将其作为一种治疗方法，但这些观察结果表明，纳洛酮可能在调节内啡肽/脑啡肽神经系统中发挥作用。
