Davidson P W, Kleene B M, Carroll M, Rockowitz R J
Appl Res Ment Retard. 1983;4(1):1-4. doi: 10.1016/s0270-3092(83)80013-7.
A clinical trial of naloxone to treat head banging behavior in a severely mentally retarded 8-year-old boy is reported. A double blind procedure was employed to concurrently contrast effects of two dosages of naloxone with saline solution placebo. No quantitatively measurable change in response rate occurred compared either with baseline or placebo. However a qualitative reduction in intensity of response was noted clinically. Implications for the use of beta-endorphine therapy for self-injurious behavior was discussed.
本文报告了一项用纳洛酮治疗一名重度智障8岁男孩撞头行为的临床试验。采用双盲程序同时对比两种剂量的纳洛酮与生理盐水安慰剂的效果。与基线或安慰剂相比，反应率没有出现可定量测量的变化。然而，临床上注意到反应强度有定性的降低。文中讨论了β-内啡肽疗法用于自伤行为的意义。
