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1
Enhanced superoxide anion release from phagocytes by muramyl dipeptide or lipopolysaccharide.胞壁酰二肽或脂多糖增强吞噬细胞中超氧阴离子的释放。
Infect Immun. 1983 Feb;39(2):559-64. doi: 10.1128/iai.39.2.559-564.1983.
2
Biphasic effects of muramyl dipeptide or lipopolysaccharide on superoxide anion-generating activities of macrophages.胞壁酰二肽或脂多糖对巨噬细胞超氧阴离子生成活性的双相效应。
Infect Immun. 1984 Jul;45(1):82-6. doi: 10.1128/iai.45.1.82-86.1984.
3
Down-regulation of Fc receptor expression in guinea pig peritoneal exudate macrophages by muramyl dipeptide or lipopolysaccharide.胞壁酰二肽或脂多糖对豚鼠腹腔渗出巨噬细胞中Fc受体表达的下调作用
J Immunol. 1985 Jun;134(6):3705-11.
4
Lipophilic derivative of muramyl dipeptide is more active than muramyl dipeptide in priming macrophages to release superoxide anion.胞壁酰二肽的亲脂性衍生物在启动巨噬细胞释放超氧阴离子方面比胞壁酰二肽更具活性。
Infect Immun. 1980 Aug;29(2):617-22. doi: 10.1128/iai.29.2.617-622.1980.
5
Oxidative metabolic response and microbicidal activity of human milk macrophages: effect of lipopolysaccharide and muramyl dipeptide.人乳巨噬细胞的氧化代谢反应及杀菌活性：脂多糖和胞壁酰二肽的作用
Infect Immun. 1985 Aug;49(2):435-9. doi: 10.1128/iai.49.2.435-439.1985.
6
Macrophage activation by muramyl dipeptide (MDP) without lymphocyte participation.在无淋巴细胞参与的情况下，胞壁酰二肽（MDP）对巨噬细胞的激活作用。
Microbiol Immunol. 1981;25(1):41-50. doi: 10.1111/j.1348-0421.1981.tb00005.x.
7
Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide.通过注射胞壁酰二肽激活巨噬细胞以增强超氧阴离子的释放及对白色念珠菌的杀伤作用。
J Exp Med. 1980 Dec 1;152(6):1659-69. doi: 10.1084/jem.152.6.1659.
8
Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide.体外暴露于胞壁酰二肽或脂多糖的巨噬细胞中超氧阴离子生成增加。
J Exp Med. 1980 Jan 1;151(1):101-14. doi: 10.1084/jem.151.1.101.
9
Human macrophages may normally be "primed" for a strong oxygen radical response.
Adv Exp Med Biol. 1983;166:215-21. doi: 10.1007/978-1-4757-1410-4_18.
10
Anthrax toxin blocks priming of neutrophils by lipopolysaccharide and by muramyl dipeptide.炭疽毒素可阻断脂多糖和胞壁酰二肽对中性粒细胞的启动作用。
J Exp Med. 1986 Nov 1;164(5):1700-9. doi: 10.1084/jem.164.5.1700.

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1
Dynamic aspect of reactive oxygen and nitric oxide in oral cavity.口腔中活性氧和一氧化氮的动态方面。
J Clin Biochem Nutr. 2008 Jan;42(1):8-13. doi: 10.3164/jcbn.2008002.
2
Suppression of the development of tumoricidal function in gamma interferon-treated human peripheral blood monocytes by lipopolysaccharide: the role of cyclooxygenase metabolites.脂多糖对γ干扰素处理的人外周血单核细胞杀瘤功能发育的抑制作用：环氧合酶代谢产物的作用
J Clin Immunol. 1993 Jan;13(1):49-57. doi: 10.1007/BF00920635.
3
Qualitative detection of muramic acid in normal mammalian tissues.正常哺乳动物组织中胞壁酸的定性检测。
Infect Immun. 1984 Mar;43(3):937-41. doi: 10.1128/iai.43.3.937-941.1984.
4
Muramyl peptides. Variation of somnogenic activity with structure.胞壁酰肽。催眠活性随结构的变化。
J Exp Med. 1984 Jan 1;159(1):68-76. doi: 10.1084/jem.159.1.68.
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Oxygen radical production by peritoneal macrophages and Kupffer cells elicited with Lactobacillus casei.干酪乳杆菌引发的腹膜巨噬细胞和枯否细胞产生氧自由基。
Infect Immun. 1984 Apr;44(1):61-7. doi: 10.1128/iai.44.1.61-67.1984.
6
Enhanced killing of Candida albicans by cultured peritoneal exudate cells treated with SM-1213, a synthetic immunomodulator.用合成免疫调节剂SM-1213处理的培养腹膜渗出细胞增强了对白色念珠菌的杀伤作用。
Antimicrob Agents Chemother. 1984 Jul;26(1):74-7. doi: 10.1128/AAC.26.1.74.
7
Biphasic effects of muramyl dipeptide or lipopolysaccharide on superoxide anion-generating activities of macrophages.胞壁酰二肽或脂多糖对巨噬细胞超氧阴离子生成活性的双相效应。
Infect Immun. 1984 Jul;45(1):82-6. doi: 10.1128/iai.45.1.82-86.1984.
8
Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme.细菌脂多糖引发中性粒细胞以增强氧代谢产物的释放。超氧化物生成酶活性增加的证据。
J Exp Med. 1984 Dec 1;160(6):1656-71. doi: 10.1084/jem.160.6.1656.
9
Phorbol myristate acetate-induced modulation of antibody-dependent cellular cytotoxicity by human polymorphonuclear leukocytes.佛波醇肉豆蔻酸酯乙酸盐对人多形核白细胞抗体依赖性细胞毒性的诱导调节作用。
Infect Immun. 1984 Dec;46(3):682-5. doi: 10.1128/iai.46.3.682-685.1984.
10
Depressed chemiluminescence response by influenza virus is enhanced after conjugation of viral subunits to muramyl dipeptide.流感病毒结合到胞壁酰二肽上后，其降低的化学发光反应会增强。
Infect Immun. 1985 Oct;50(1):146-51. doi: 10.1128/iai.50.1.146-151.1985.

本文引用的文献

1
Increased production of superoxide anion by macrophages exposed in vitro to muramyl dipeptide or lipopolysaccharide.体外暴露于胞壁酰二肽或脂多糖的巨噬细胞中超氧阴离子生成增加。
J Exp Med. 1980 Jan 1;151(1):101-14. doi: 10.1084/jem.151.1.101.
2
Macrophage activation by muramyl dipeptide (MDP) without lymphocyte participation.在无淋巴细胞参与的情况下，胞壁酰二肽（MDP）对巨噬细胞的激活作用。
Microbiol Immunol. 1981;25(1):41-50. doi: 10.1111/j.1348-0421.1981.tb00005.x.
3
Simultaneous demonstration of phagocytosis-connected oxygen consumption and corresponding NAD(P)H oxidase activity: direct evidence for NADPH as the predominant electron donor to oxygen in phagocytizing human neutrophils.
Biochem Biophys Res Commun. 1981 Feb 12;98(3):743-51. doi: 10.1016/0006-291x(81)91175-x.
4
Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate.用合成的胞壁酰二肽和海藻糖二霉菌酸酯治疗后豚鼠肿瘤的消退。
Science. 1980 Apr 25;208(4442):415-6. doi: 10.1126/science.7189295.
5
Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators.巨噬细胞在静脉注射含巨噬细胞激活剂的脂质体后对已形成转移灶的清除作用。
Cancer Res. 1982 Feb;42(2):496-501.
6
Epithelioid granuloma formation requiring no T-cell function.无需T细胞功能的上皮样肉芽肿形成。
Am J Pathol. 1982 Feb;106(2):165-70.
7
Epithelioid granuloma induced by muramyl dipeptide in immunologically deficient rats.免疫缺陷大鼠中胞壁酰二肽诱导的上皮样肉芽肿
Infect Immun. 1981 Dec;34(3):993-9. doi: 10.1128/iai.34.3.993-999.1981.
8
Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.自由基与炎症：血浆中中性粒细胞趋化因子的超氧化物依赖性激活
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1159-63. doi: 10.1073/pnas.77.2.1159.
9
Alveolar macrophage lipoxygenase products of arachidonic acid: isolation and recognition as the predominant constituents of the neutrophil chemotactic activity elaborated by alveolar macrophages.肺泡巨噬细胞花生四烯酸的脂氧合酶产物：分离及被确认为肺泡巨噬细胞产生的中性粒细胞趋化活性的主要成分。
Cell Immunol. 1980 Sep 1;54(2):390-401. doi: 10.1016/0008-8749(80)90219-1.
10
Epithelioid granuloma formation by a synthetic bacterial cell wall component, muramyl dipeptide (MDP).由合成细菌细胞壁成分胞壁酰二肽（MDP）形成上皮样肉芽肿。
Am J Pathol. 1980 Mar;98(3):733-48.

胞壁酰二肽或脂多糖增强吞噬细胞中超氧阴离子的释放。

Enhanced superoxide anion release from phagocytes by muramyl dipeptide or lipopolysaccharide.

作者信息

Kaku M, Yagawa K, Nagao S, Tanaka A

出版信息

Infect Immun. 1983 Feb;39(2):559-64. doi: 10.1128/iai.39.2.559-564.1983.

DOI:10.1128/iai.39.2.559-564.1983
PMID:6299943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC347987/
Abstract

Muramyl dipeptide (MDP) and lipopolysaccharide (LPS) from Escherichia coli were tested for the ability to influence superoxide anion (O2-) release from guinea pig phagocytes. Both MDP and LPS alone did not, by themselves, stimulate O2- release by macrophages and polymorphonuclear leukocytes. However, the preincubation of macrophages with MDP or LPS primed the macrophages to release an enhanced amount of O2- when stimulated by cytochalasin E and wheat germ agglutinin. When polymorphonuclear leukocytes were treated in the same way, only LPS showed an enhancing effect. MDP enhanced NADPH oxidase activity of macrophages, which is probably the reason for enhanced O2- release by MDP.

摘要

对来自大肠杆菌的胞壁酰二肽（MDP）和脂多糖（LPS）影响豚鼠吞噬细胞释放超氧阴离子（O2-）的能力进行了测试。单独的MDP和LPS本身均不会刺激巨噬细胞和多形核白细胞释放O2-。然而，用MDP或LPS对巨噬细胞进行预孵育，可使巨噬细胞在受到细胞松弛素E和麦胚凝集素刺激时释放出更多的O2-。当以同样方式处理多形核白细胞时，只有LPS显示出增强作用。MDP增强了巨噬细胞的NADPH氧化酶活性，这可能是MDP导致O2-释放增加的原因。