用合成的胞壁酰二肽和海藻糖二霉菌酸酯治疗后豚鼠肿瘤的消退。
Regression of tumors in guinea pigs after treatment with synthetic muramyl dipeptides and trehalose dimycolate.
作者信息
McLaughlin C A, Schwartzman S M, Horner B L, Jones G H, Moffatt J G, Nestor J J, Tegg D
出版信息
Science. 1980 Apr 25;208(4442):415-6. doi: 10.1126/science.7189295.
PMID:7189295
Abstract
A high incidence of tumor regression was observed in guinea pigs bearing transplantable, line-10 hepatocellular carcinomas when synthetic muramyl dipeptides combined with trehalose dimycolate in oil-in-water emulsions were injected directly into the tumors. These compounds are promising candidates to replace viable bacillus Calmette-Guérin in cancer immunotherapy in humans and animals.
摘要
当将合成的胞壁酰二肽与海藻糖二霉菌酸酯在水包油乳剂中混合后直接注射到荷有可移植的10号线肝细胞癌的豚鼠肿瘤内时，观察到肿瘤消退的发生率很高。这些化合物有望替代活的卡介苗，用于人类和动物的癌症免疫治疗。
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