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Structure and function of the hepatitis B virus genome.

作者信息

Will H, Kuhn C, Cattaneo R, Schaller H

出版信息

Princess Takamatsu Symp. 1982;12:237-47.

PMID:6300022
Abstract

A preliminary map of the hepatitis B virus genome has been derived from the nucleotide sequence of cloned human hepatitis virus (HBV) DNA. The genes for two viral antigens were identified and their expression was studied using SV40 vector systems. HBV DNA cloned and amplified in bacteria induces hepatitis in chimpanzees demonstrating that the cloned HBV DNA is functionally intact.

摘要

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引用本文的文献

1
Expression of hepatitis B antigens with a simian virus 40 vector.用猿猴病毒40载体表达乙型肝炎抗原。
J Virol. 1984 May;50(2):335-42. doi: 10.1128/JVI.50.2.335-342.1984.
2
Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region.人类乙型肝炎病毒整合位点在肝癌中靠近三链区域处紧密聚集。
J Virol. 1987 Nov;61(11):3491-8. doi: 10.1128/JVI.61.11.3491-3498.1987.
3
X-region-specific transcript in mammalian hepatitis B virus-infected liver.哺乳动物感染乙型肝炎病毒的肝脏中的X区域特异性转录本。
J Virol. 1988 Nov;62(11):3979-84. doi: 10.1128/JVI.62.11.3979-3984.1988.
4
Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen.在持续感染的宿主中，伴有e抗原抗体血清学转换的前核心区缺陷型乙型肝炎病毒较为普遍。
J Virol. 1990 Mar;64(3):1298-303. doi: 10.1128/JVI.64.3.1298-1303.1990.
5
Defective replication units of hepatitis B virus.
J Virol. 1990 Apr;64(4):1851-4. doi: 10.1128/JVI.64.4.1851-1854.1990.
6
Hepatitis B virus core antigen has two nuclear localization sequences in the arginine-rich carboxyl terminus.乙肝病毒核心抗原在富含精氨酸的羧基末端有两个核定位序列。
J Virol. 1991 Feb;65(2):575-82. doi: 10.1128/JVI.65.2.575-582.1991.