大鼠纤维蛋白原基因。Aα链和γ链基因的连锁关系。
The rat fibrinogen genes. Linkage of the A alpha and gamma chain genes.
作者信息
Kant J A, Crabtree G R
出版信息
J Biol Chem. 1983 Apr 25;258(8):4666-7.
PMID:6300095
Abstract
We have utilized cDNA probes for the alpha, beta, and gamma chains of rat fibrinogen to isolate the corresponding genes from two rat genomic libraries constructed in bacteriophage Charon 4A. There is a single copy of each gene. Mapping of greater than 92 kilobase pairs of rat genomic DNA has shown that the gamma and alpha chain genes are directly linked in a 5'-3' direction in vivo.
摘要
我们利用大鼠纤维蛋白原α、β和γ链的cDNA探针，从两个用噬菌体Charon 4A构建的大鼠基因组文库中分离出相应的基因。每个基因都只有一个拷贝。对超过92千碱基对的大鼠基因组DNA进行图谱分析表明，γ链和α链基因在体内以5'-3'方向直接相连。
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