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一种内皮细胞衍生生长因子。

An endothelial cell-derived growth factor.

作者信息

Gajdusek C, DiCorleto P, Ross R, Schwartz S M

出版信息

J Cell Biol. 1980 May;85(2):467-72. doi: 10.1083/jcb.85.2.467.

DOI:10.1083/jcb.85.2.467
PMID:7372716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2110613/
Abstract

Cell-free plasma-derived serum (PDS) is deficient in the platelet-derived growth factor and will not support the growth of 3T3 cells, fibroblasts, or smooth muscle cells. However, when PDS-containing medium is preincubated with endothelial cells, the medium becomes modified so that it will support growth. The activity produced by the endothelial cells results from a polypeptide of 10,000 to 30,000 daltons which has several features that differ from those of the platelet-derived growth factor, including heat instability and lack of adsorption to CM Sephadex.

摘要

无细胞血浆衍生血清（PDS）缺乏血小板衍生生长因子，无法支持3T3细胞、成纤维细胞或平滑肌细胞的生长。然而，当含PDS的培养基与内皮细胞预孵育时，培养基会发生改变，从而能够支持细胞生长。内皮细胞产生的活性物质是一种分子量为10,000至30,000道尔顿的多肽，它具有一些与血小板衍生生长因子不同的特性，包括热不稳定性和不吸附于CM Sephadex。

相似文献

1
An endothelial cell-derived growth factor.一种内皮细胞衍生生长因子。
J Cell Biol. 1980 May;85(2):467-72. doi: 10.1083/jcb.85.2.467.
2
Cultured endothelial cells produce a platelet-derived growth factor-like protein.培养的内皮细胞产生一种血小板衍生生长因子样蛋白。
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3
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Mediation of pinocytosis in cultured arterial smooth muscle and endothelial cells by platelet-derived growth factor.血小板衍生生长因子对培养的动脉平滑肌细胞和内皮细胞中胞饮作用的介导
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Potent stimulation of vascular endothelial cell growth by differentiated 3T3 adipocytes.分化的3T3脂肪细胞对血管内皮细胞生长的强烈刺激。
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6
In vitro and in vivo effects of endothelial cell-derived growth factor.内皮细胞衍生生长因子的体外和体内效应
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Cultured endothelial cells produce a heparinlike inhibitor of smooth muscle cell growth.培养的内皮细胞产生一种平滑肌细胞生长的类肝素抑制剂。
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10
Mouse hepatic endothelial cells in culture secrete a growth inhibitor for hepatic lipocytes and Balb/c 3T3 fibroblasts.培养中的小鼠肝内皮细胞分泌一种针对肝脂肪细胞和Balb/c 3T3成纤维细胞的生长抑制剂。
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Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway.内皮细胞通过机械敏感的自分泌转化生长因子-β信号通路对血管重塑提供反馈控制。
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Trans Am Clin Climatol Assoc. 1982;93:78-86.
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本文引用的文献

1
The initiation of cell division in a contact-inhibited mammalian cell line.接触抑制的哺乳动物细胞系中细胞分裂的起始
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Stimulation of RNA synthesis and cell division in resting cells by a factor present in serum.血清中一种因子对静息细胞RNA合成和细胞分裂的刺激作用。
Wistar Inst Symp Monogr. 1967;7:87-101.
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Some characteristics of a factor stimulating skin epithelial cell growth in vitro.一种体外刺激皮肤上皮细胞生长的因子的某些特性。
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Identification of a growth factor produced by human fibroblasts in vitro as putrescine.鉴定人成纤维细胞在体外产生的一种生长因子为腐胺。
Nat New Biol. 1972 Feb 23;235(60):247-9. doi: 10.1038/newbio235247a0.
5
Isolation and characterization of revertant cell lines. II. Growth control of a polyploid revertant line derived from SV40-transformed 3T3 mouse cells.回复细胞系的分离与特性鉴定。II. 源自SV40转化的3T3小鼠细胞的多倍体回复系的生长控制
J Cell Physiol. 1973 Aug;82(1):93-100. doi: 10.1002/jcp.1040820111.
6
The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers.平滑肌细胞。II. 培养中平滑肌的生长及弹性纤维的形成。
J Cell Biol. 1971 Jul;50(1):172-86. doi: 10.1083/jcb.50.1.172.
7
Control by factors in serum of multiplication of uninfected cells and cells infected and converted by avian sarcoma viruses.血清中各因素对未感染细胞以及被禽肉瘤病毒感染并转化的细胞增殖的控制。
Wistar Inst Symp Monogr. 1967;7:103-16.
8
A platelet factor stimulating human normal glial cells.一种刺激人正常神经胶质细胞的血小板因子。
Exp Cell Res. 1976 Mar 1;98(1):170-4. doi: 10.1016/0014-4827(76)90476-6.
9
Isolation of a cationic polypeptide from human serum that stimulates proliferation of 3T3 cells.从人血清中分离出一种可刺激3T3细胞增殖的阳离子多肽。
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2635-9. doi: 10.1073/pnas.72.7.2635.
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A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro.一种在体外刺激成纤维细胞增殖的巨噬细胞依赖性因子。
Am J Pathol. 1976 Sep;84(3):501-14.