钙离子对爆发式神经元的影响。一项建模研究。
The effects of calcium++ on bursting neurons. A modeling study.
作者信息
Plant R E
出版信息
Biophys J. 1978 Mar;21(3):217-37. doi: 10.1016/S0006-3495(78)85521-0.
Abstract
Many observed effects of ionized calcium on bursting pacemaker neurons may be accounted for by assuming that calcium has multiple effects on the membrane conductance mechanisms. Two models are proposed that represent extreme cases of a set of possible models for these multiple effects. Both models are a priori designed to account for directly observed phenomena, and both are found to be able to simulate a posteriori certain observed phenomena, including persistent inactivation, increasing spike width, and decreasing after-polarization. Experimental tests are proposed for the decision of validity between the set of models discussed and the null hypothesis, and for the decision of validity between the two models themselves. Extensions of the models are discussed. One of these extensions leads to a simulation of the behavior of the cell when placed in a calcium-free bathing medium.
摘要
许多关于离子钙对爆发性起搏神经元的观察效应，可以通过假设钙对膜电导机制有多种作用来解释。提出了两种模型，它们代表了一组关于这些多种作用的可能模型中的极端情况。这两种模型都是先验设计用来解释直接观察到的现象，并且发现它们都能够后验地模拟某些观察到的现象，包括持续性失活、增加动作电位宽度以及减小后超极化。提出了实验测试，用于在讨论的模型集与零假设之间判定有效性，以及在这两个模型本身之间判定有效性。还讨论了模型的扩展。其中一种扩展导致了对细胞置于无钙浴液中的行为的模拟。
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