两种“睡眠”肽，即δ睡眠诱导肽和精氨酸血管催产素，对大鼠和兔脑干单个神经元作用的比较。
Comparison of the effects of two 'sleep' peptides, delta sleep-inducing peptide and arginine-vasotocin, on single neurons in the rat and rabbit brain stem.
作者信息
Normanton J R, Gent J P
出版信息
Neuroscience. 1983 Jan;8(1):107-14. doi: 10.1016/0306-4522(83)90029-5.
The effects of delta sleep-inducing peptide and arginine-vasotocin were assessed on single neurons in the nucleus reticularis gigantocellularis of the brain stem in rats and rabbits. Both peptides showed predominantly excitatory actions in both species when applied by microiontophoresis. A small proportion of cells was inhibited by delta sleep-inducing peptide in the rat. Responses to delta sleep-inducing peptide were short-lasting, dose-dependent and showed no significant desensitization to repeated applications. Responses to arginine-vasotocin were of very long time course and showed profound desensitization. No statistically significant correlation was seen between cells responsive to delta sleep-inducing peptide and those responsive to arginine-vasotocin. We conclude that both 'sleep' peptides have similar actions on central neurons and that they are active in both rats and rabbits. However, no evidence was found to suggest a common mechanism of action for both substances.
在大鼠和家兔脑干巨细胞网状核的单个神经元上评估了δ-促睡眠肽和精氨酸血管催产素的作用。当通过微离子透入法应用这两种肽时，在这两个物种中它们主要表现出兴奋作用。在大鼠中，一小部分细胞被δ-促睡眠肽抑制。对δ-促睡眠肽的反应是短暂的、剂量依赖性的，并且对重复应用没有明显的脱敏现象。对精氨酸血管催产素的反应具有很长的时程并且表现出深度脱敏。对δ-促睡眠肽有反应的细胞和对精氨酸血管催产素有反应的细胞之间未发现统计学上的显著相关性。我们得出结论，这两种“睡眠”肽对中枢神经元有相似的作用，并且它们在大鼠和家兔中均有活性。然而，没有证据表明这两种物质有共同的作用机制。
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