Graf M V, Kastin A J
Neurosci Biobehav Rev. 1984 Spring;8(1):83-93. doi: 10.1016/0149-7634(84)90022-8.
Since the turn of the century, it has been postulated that humoral factors induce sleep. Many compounds were proposed as sleep-factors, but only two of the sleep-peptides have been purified to homogeneity and characterized, so far. One of them, DSIP, was shown to be a nonapeptide of MW 849 and to induce mainly delta-sleep in rabbits, rats, mice, and humans, whereas in cats, the effect on REM sleep was more pronounced. A U-shaped activity curve was determined for the dose as well as for the time of infusion. DSIP-like material was found by RIA and immunohistochemistry in brain and by RIA in peripheral organs of the rat as well as in plasma of several mammals. In addition to sleep, the peptide also has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal.
自世纪之交以来，人们就推测体液因素会诱导睡眠。许多化合物被提议作为睡眠因子，但迄今为止，只有两种睡眠肽被纯化至同质并进行了表征。其中一种，即DSIP，被证明是一种分子量为849的九肽，主要诱导兔、大鼠、小鼠和人类的δ睡眠，而在猫中，对快速眼动睡眠的影响更为明显。确定了剂量和输注时间的U形活性曲线。通过放射免疫分析（RIA）和免疫组织化学在大鼠脑内以及通过RIA在大鼠外周器官和几种哺乳动物的血浆中发现了DSIP样物质。除了睡眠外，还观察到该肽会影响电生理活动、脑内神经递质水平、昼夜节律和运动模式、激素水平、心理表现以及包括撤药在内的神经药理学药物的活性。
