Laky D, Constantinescu S, Filipescu G, Constantinescu N M, Ratea E, Halalau F
Acta Morphol Acad Sci Hung. 1982;30(3-4):299-307.
The biology of the myocardium was studied under experimental conditions similar to angina pectoris. In some dogs the myocardium was adapted to ischaemia by progressive coronary occlusion of 1-5 min followed by restoration of circulation during 5 min. In other dogs adaption was followed by 20 to 35 min ischaemia. The animals were sacrificed immediately or after 2-10 days. Transient ischaemia produced less severe alterations then abrupt coronary obstruction. Adaptation followed by 20 and 35 min ischaemia induced foci that undergo cytolysis and scarring of maximum intensity on the 8th day. Activity of enzymes in the mitochondrial suspension, especially of cytochromoxidase, decreases and lysosomal hydrolases increase with focal necroses.
在类似于心绞痛的实验条件下研究了心肌生物学。在一些狗中，通过逐渐进行1 - 5分钟的冠状动脉闭塞，随后在5分钟内恢复循环，使心肌适应缺血。在其他狗中，适应后进行20至35分钟的缺血。动物在缺血后立即处死或在2 - 10天后处死。短暂性缺血产生的改变比冠状动脉突然阻塞要轻。适应后进行20分钟和35分钟缺血会诱发病灶，这些病灶在第8天会发生最大程度的细胞溶解和瘢痕形成。随着局灶性坏死，线粒体悬液中酶的活性，尤其是细胞色素氧化酶的活性降低，而溶酶体水解酶活性增加。
