Laky D, Constantinescu S, Filipescu G, Constantinescu N M, Ratea E, Hâlâlâu F
Morphol Embryol (Bucur). 1980 Apr-Jun;26(2):173-7.
The first ten days' evolution of post-ischaemic lesions of the premonitory or angina pectoris syndrome type was experimentally studied by the challenge of a short-term (10 and 15 min) ischaemia, of an adaptation to ischaemia and an adaptation followed by prolonged ischaemia (20 and 35 min). Worthy of note was the persistence of reversible lesions after short-term ischaemia and adaptation, and the progressive evolution towards cytolysis and cicatrization of some pancicellular foci after adaptation followed by prolonged ischaemia. The role of mitochondrial lesions, of lysosomal hydrolases, the inefficiency of renewed circulation, as well as problems of diagnosis are discussed.
通过短期（10分钟和15分钟）缺血刺激、缺血适应以及缺血适应后再进行长时间缺血（20分钟和35分钟），对先兆或心绞痛综合征类型的缺血后病变的前十天演变进行了实验研究。值得注意的是，短期缺血和适应后可逆性病变持续存在，而在缺血适应后再进行长时间缺血时，一些全细胞病灶会逐渐演变为细胞溶解和瘢痕形成。文中讨论了线粒体病变、溶酶体水解酶的作用、再灌注的无效性以及诊断问题。
