González P H, Laguens R P, Frigerio M J, Calello M A, Weissenbacher M C
Am J Trop Med Hyg. 1983 Mar;32(2):417-23. doi: 10.4269/ajtmh.1983.32.417.
Infection of Callithrix jacchus, a New World primate, with the prototype strain of Junin virus produced a severe disease. The animals developed multifocal hemorrhages and characteristic microscopic lesions such as meningoencephalitis, interstitial pneumonia, lymphocytic depletion of lymphatic tissue, hepatocytic necrosis, and a variable decrease in bone marrow cellularity. High virus concentrations correlated with lesions, and with the presence of viral antigenic determinants as revealed by immunofluorescent methods. With the exception of central nervous system damage, the morphological features and immunohistochemical and viral findings were similar to those recorded in human Argentine hemorrhagic fever.
新世界灵长类动物狨猴感染胡宁病毒原型毒株后引发了严重疾病。这些动物出现了多灶性出血以及特征性的微观病变，如脑膜脑炎、间质性肺炎、淋巴组织淋巴细胞耗竭、肝细胞坏死，以及骨髓细胞数量不同程度减少。高病毒浓度与病变以及免疫荧光法所显示的病毒抗原决定簇的存在相关。除中枢神经系统损伤外，其形态学特征、免疫组织化学及病毒学发现与人类阿根廷出血热中所记录的相似。
