头孢曲松与普鲁卡因青霉素G水剂治疗女性单纯性淋病的对比研究
Comparative study of ceftriaxone and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in women.
作者信息
Judson F N, Ehret J M, Root C J
出版信息
Antimicrob Agents Chemother. 1983 Feb;23(2):218-20. doi: 10.1128/AAC.23.2.218.
Abstract
Uncomplicated gonorrhea of 122 mucosal sites in 51 women was successfully treated with either a single intramuscular dose of 250 mg of ceftriaxone (23 patients) or two intramuscular doses of 4.8 X 10(6) U of aqueous procaine penicillin G (28 patients). Women treated with ceftriaxone had 22 cervical, 12 urethral, 10 anal canal, and 5 pharyngeal infections. All 122 pretreatment isolates were inhibited by 0.0125 microgram or less of ceftriaxone per ml. The minimal concentration needed to inhibit 90% of isolates was 0.006 microgram/ml for ceftriaxone and 0.2 microgram/ml for penicillin G. Ceftriaxone was very well tolerated and caused no toxicity.
摘要
51名女性的122个黏膜部位的单纯性淋病，采用单次肌内注射250mg头孢曲松（23例患者）或两次肌内注射4.8×10⁶U普鲁卡因青霉素G（28例患者）均成功治愈。接受头孢曲松治疗的女性有22例宫颈感染、12例尿道感染、10例肛管感染和5例咽部感染。所有122株治疗前分离株均被每毫升0.0125微克或更低浓度的头孢曲松抑制。抑制90%分离株所需的最低浓度，头孢曲松为0.006微克/毫升，青霉素G为0.2微克/毫升。头孢曲松耐受性良好，未引起毒性反应。
相似文献
1
Comparative study of ceftriaxone and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea in women.头孢曲松与普鲁卡因青霉素G水剂治疗女性单纯性淋病的对比研究
Antimicrob Agents Chemother. 1983 Feb;23(2):218-20. doi: 10.1128/AAC.23.2.218.
2
Comparative study of ceftriaxone and spectinomycin in the treatment of uncomplicated gonorrhea in women.头孢曲松与大观霉素治疗女性单纯性淋病的对比研究。
Am J Med. 1984 Oct 19;77(4C):68-72.
3
Treatment of gonorrhea: comparison of cefotaxime and penicillin.淋病的治疗：头孢噻肟与青霉素的比较
Antimicrob Agents Chemother. 1981 May;19(5):798-800. doi: 10.1128/AAC.19.5.798.
4
Dose-ranging study of ceftriaxone for uncomplicated gonorrhea in men.头孢曲松治疗男性单纯性淋病的剂量范围研究。
Antimicrob Agents Chemother. 1981 Dec;20(6):839-40. doi: 10.1128/AAC.20.6.839.
5
Treatment of uncomplicated gonorrhea with ceftriaxone: a review.用头孢曲松治疗单纯性淋病：综述
Sex Transm Dis. 1986 Jul-Sep;13(3 Suppl):199-202. doi: 10.1097/00007435-198607000-00021.
6
Comparative study of ceftriaxone and spectinomycin for treatment of uncomplicated gonorrhoea in men.头孢曲松与大观霉素治疗男性单纯性淋病的对比研究
Lancet. 1983 Jul 9;2(8341):67-70. doi: 10.1016/s0140-6736(83)90058-2.
7
Comparative study of ceftriaxone and spectinomycin for treatment of pharyngeal and anorectal gonorrhea.
JAMA. 1985 Mar 8;253(10):1417-9.
8
Treatment of uncomplicated gonorrhea with cefotaxime.用头孢噻肟治疗单纯性淋病。
Sex Transm Dis. 1981 Jul-Sep;8(3):187-91. doi: 10.1097/00007435-198107000-00003.
9
Comparison of ceftizoxime and penicillin for the treatment of uncomplicated gonorrhoea.
J Antimicrob Chemother. 1982 Nov;10 Suppl C:229-35. doi: 10.1093/jac/10.suppl_c.229.
10
Oral cefixime versus intramuscular ceftriaxone in patients with uncomplicated gonococcal infections.单纯性淋菌感染患者口服头孢克肟与肌内注射头孢曲松的对比研究
Sex Transm Dis. 1992 Mar-Apr;19(2):94-8.
引用本文的文献
1
Safety Aspects and Rational Use of Single Intramuscular Dose Ceftriaxone: Clinical Insights on the Management of Uncomplicated Gonococcal Infections.单次肌内注射头孢曲松的安全性及合理使用：单纯性淋菌感染管理的临床见解
Drug Healthc Patient Saf. 2023 Nov 3;15:159-170. doi: 10.2147/DHPS.S350763. eCollection 2023.
2
Efficacy and Safety of Injectable and Oral Antibiotics in Treating Gonorrhea: A Systematic Review and Network Meta-Analysis.注射用和口服抗生素治疗淋病的疗效与安全性：一项系统评价和网状Meta分析
J Clin Med. 2019 Dec 11;8(12):2182. doi: 10.3390/jcm8122182.
3
The use of cephalosporins for gonorrhea: the impending problem of resistance.头孢菌素用于淋病治疗：迫在眉睫的耐药性问题。
Expert Opin Pharmacother. 2009 Mar;10(4):555-77. doi: 10.1517/14656560902731993.
4
Ceftriaxone. A review of its antibacterial activity, pharmacological properties and therapeutic use.头孢曲松。对其抗菌活性、药理特性及治疗用途的综述。
Drugs. 1984 Jun;27(6):469-527. doi: 10.2165/00003495-198427060-00001.
5
The potential uses of ceftriaxone.头孢曲松的潜在用途。
Eur J Clin Microbiol. 1983 Oct;2(5):485-8. doi: 10.1007/BF02013913.
6
Single-dose ceftriaxone versus multiple-dose trimethoprim-sulfamethoxazole in the treatment of acute urinary tract infections.单剂量头孢曲松与多剂量甲氧苄啶-磺胺甲恶唑治疗急性尿路感染的比较
Antimicrob Agents Chemother. 1985 Feb;27(2):158-61. doi: 10.1128/AAC.27.2.158.
7
Role of cephalosporins in gonorrhoea and other sexually transmitted diseases.头孢菌素在淋病及其他性传播疾病中的作用。
Drugs. 1987;34 Suppl 2:164-79. doi: 10.2165/00003495-198700342-00013.
8
Randomised comparative study of ceftriaxone and spectinomycin in gonorrhoea.头孢曲松与大观霉素治疗淋病的随机对照研究。
Genitourin Med. 1985 Apr;61(2):106-8. doi: 10.1136/sti.61.2.106.
9
Randomised observer blind comparative trial of ceftriaxone and penicillin in treating uncomplicated gonorrhoea in men and women.头孢曲松与青霉素治疗男女单纯性淋病的随机观察者盲法对照试验
Genitourin Med. 1986 Apr;62(2):78-81. doi: 10.1136/sti.62.2.78.
10
Ceftriaxone. A reappraisal of its antibacterial activity and pharmacokinetic properties, and an update on its therapeutic use with particular reference to once-daily administration.头孢曲松。对其抗菌活性和药代动力学特性的重新评估，以及关于其治疗用途的最新情况，特别提及每日一次给药。
Drugs. 1988 Jun;35(6):604-45. doi: 10.2165/00003495-198835060-00002.
本文引用的文献
1
Antibacterial activity of ceftriaxone (Ro 13-9904), a beta-lactamase-stable cephalosporin.头孢曲松（Ro 13 - 9904）的抗菌活性，一种对β-内酰胺酶稳定的头孢菌素。
Antimicrob Agents Chemother. 1981 Mar;19(3):414-23. doi: 10.1128/AAC.19.3.414.
2
In vitro antibacterial activity and susceptibility of the cephalosporin Ro 13-9904 to beta-lactamases.头孢菌素Ro 13-9904对β-内酰胺酶的体外抗菌活性及敏感性
Antimicrob Agents Chemother. 1980 Aug;18(2):292-8. doi: 10.1128/AAC.18.2.292.
3
Comparison of the activities of ceftriaxone and penicillin G against experimentally induced syphilis in rabbits.头孢曲松与青霉素G针对兔实验性梅毒的活性比较。
Antimicrob Agents Chemother. 1982 Jun;21(6):984-9. doi: 10.1128/AAC.21.6.984.
4
Pharmacokinetics and tolerance of ceftriaxone in humans after single-dose intramuscular administration in water and lidocaine diluents.头孢曲松在水中和利多卡因稀释剂中单剂量肌内注射后在人体中的药代动力学和耐受性。
Antimicrob Agents Chemother. 1982 Jun;21(6):957-62. doi: 10.1128/AAC.21.6.957.
5
Dose-ranging study of ceftriaxone for uncomplicated gonorrhea in men.头孢曲松治疗男性单纯性淋病的剂量范围研究。
Antimicrob Agents Chemother. 1981 Dec;20(6):839-40. doi: 10.1128/AAC.20.6.839.
6
In vitro susceptibility of Haemophilus influenzae and neisseria gonorrhoeae to Ro 13-9904 in comparison with other beta-lactam antibiotics.流感嗜血杆菌和淋病奈瑟菌对Ro 13-9904与其他β-内酰胺类抗生素的体外敏感性比较。
Antimicrob Agents Chemother. 1981 May;19(5):925-6. doi: 10.1128/AAC.19.5.925.
7
Comparative in-vitro activity and mode of action of ceftriaxone (Ro 13-9904), a new highly potent cephalosporin.
J Antimicrob Chemother. 1981 Sep;8(3):193-203. doi: 10.1093/jac/8.3.193.
Zotero 插件