McCracken G H, Siegel J D, Threlkeld N, Thomas M
Antimicrob Agents Chemother. 1983 Feb;23(2):341-3. doi: 10.1128/AAC.23.2.341.
Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 micrograms/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.
在40名年龄为1至45天的新生儿中测定了头孢曲松的药代动力学。在每千克静脉注射50毫克头孢曲松15分钟结束时，观察到平均血浆峰值浓度为136至173微克/毫升。平均半衰期值为5.2至8.4小时，平均血浆清除率为0.7至1.8毫升/分钟。16名婴儿中有14名的直肠拭子培养物在治疗期间需氧菌和厌氧菌数量减少或无生长。建议对新生儿进行头孢曲松治疗时采用每日一次的给药方案。
