Daschner F D, Petersen E E, Brändle J, Hillemanns H G
Chemotherapy. 1983;29(2):153-5. doi: 10.1159/000238189.
31 patients received an intravenous 15-min injection of 2 g ceftriaxone at various times before abdominal or vaginal hysterectomy. Ceftriaxone concentrations in salpinges were significantly higher than in myometrium and endometrium. Tissue concentrations of 20 micrograms/g could be maintained for at least 5 h. Due to its high tissue concentrations maintained for the whole operative procedure, ceftriaxone does seem to be one of the antibiotics of choice for single-dose prophylaxis of postoperative infections in gynecology.
31例患者在腹部或阴道子宫切除术前行不同时间的静脉注射2g头孢曲松15分钟。输卵管中头孢曲松的浓度显著高于子宫肌层和子宫内膜。组织浓度为20微克/克时可维持至少5小时。由于在整个手术过程中维持了高组织浓度，头孢曲松似乎是妇科单剂量预防术后感染的首选抗生素之一。
