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本文引用的文献

1
Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis.羟羧氧酰胺菌素、头孢噻肟、头孢哌酮和头孢曲松在实验性细菌性脑膜炎中的药代动力学及细菌学疗效
J Infect Dis. 1981 Feb;143(2):156-63. doi: 10.1093/infdis/143.2.156.
2
In vitro susceptibility of gram-negative bacilli from pediatric patients to moxalactam, cefotaxime, Ro 13-9904, and other cephalosporins.儿科患者革兰氏阴性杆菌对羟羧氧酰胺菌素、头孢噻肟、Ro 13-9904及其他头孢菌素的体外敏感性
Antimicrob Agents Chemother. 1980 Sep;18(3):476-9. doi: 10.1128/AAC.18.3.476.

头孢噻肟在新生儿中的药代动力学

Pharmacokinetics of cefotaxime in newborn infants.

作者信息

McCracken G H, Threlkeld N E, Thomas M L

出版信息

Antimicrob Agents Chemother. 1982 Apr;21(4):683-4. doi: 10.1128/AAC.21.4.683.

DOI:10.1128/AAC.21.4.683
PMID:6282216
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC181970/
Abstract

The pharmacokinetics of cefotaxime were determined in newborn infants who were 1 to 7 days of age. Mean peak serum concentrations of 116 and 132 micrograms/ml were observed at completion of a 10-min intravenous infusion of 50 mg of cefotaxime per kg in low and average birth weight infants, respectively. The mean elimination half-lives were 4.6 and 3.4 h and rates of clearance from serum were 23 and 44 ml/min per 1.73 m2, respectively. A dosage schedule for cefotaxime in newborn infants is presented.

摘要

在1至7日龄的新生儿中测定了头孢噻肟的药代动力学。在低出生体重和平均出生体重的婴儿中，每公斤静脉注射50毫克头孢噻肟10分钟结束时，平均血清峰值浓度分别为116和132微克/毫升。平均消除半衰期分别为4.6小时和3.4小时，血清清除率分别为每1.73平方米23毫升/分钟和44毫升/分钟。本文给出了新生儿头孢噻肟的给药方案。