头孢噻肟在新生儿中的药代动力学
Pharmacokinetics of cefotaxime in newborn infants.
作者信息
McCracken G H, Threlkeld N E, Thomas M L
出版信息
Antimicrob Agents Chemother. 1982 Apr;21(4):683-4. doi: 10.1128/AAC.21.4.683.
Abstract
The pharmacokinetics of cefotaxime were determined in newborn infants who were 1 to 7 days of age. Mean peak serum concentrations of 116 and 132 micrograms/ml were observed at completion of a 10-min intravenous infusion of 50 mg of cefotaxime per kg in low and average birth weight infants, respectively. The mean elimination half-lives were 4.6 and 3.4 h and rates of clearance from serum were 23 and 44 ml/min per 1.73 m2, respectively. A dosage schedule for cefotaxime in newborn infants is presented.
摘要
在1至7日龄的新生儿中测定了头孢噻肟的药代动力学。在低出生体重和平均出生体重的婴儿中，每公斤静脉注射50毫克头孢噻肟10分钟结束时，平均血清峰值浓度分别为116和132微克/毫升。平均消除半衰期分别为4.6小时和3.4小时，血清清除率分别为每1.73平方米23毫升/分钟和44毫升/分钟。本文给出了新生儿头孢噻肟的给药方案。
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