Wheat L J, Smith E J, Sathapatayavongs B, Batteiger B, Filo R S, Leapman S B, French M V
Arch Intern Med. 1983 Apr;143(4):703-7.
During two large outbreaks, ten episodes of histoplasmosis were documented in eight renal allograft recipients. Another episode occurred before the outbreaks. Associated infections with cytomegalovirus occurred in five patients and may have further impaired cellular immunity. Prolonged fever was the predominant clinical finding; and dissemination was observed in seven of our nine patients, including three with meningitis. Special stains of tissues and the histoplasmal complement fixation test provided useful diagnostic information rapidly, while cultures were eventually positive in seven patients. Treatment with amphotericin B resulted in prompt clinical improvement in all patients, but relapse occurred in two patients one year following therapy.
在两次大规模疫情期间，8名肾移植受者中记录到10例组织胞浆菌病发作。在疫情爆发前还发生了1例。5名患者发生了巨细胞病毒相关感染，这可能进一步损害了细胞免疫。长期发热是主要的临床症状；在我们的9名患者中，有7名出现了播散，其中3名患有脑膜炎。组织特殊染色和组织胞浆菌补体结合试验能迅速提供有用的诊断信息，而7名患者的培养最终呈阳性。两性霉素B治疗使所有患者的临床症状迅速改善，但2名患者在治疗1年后复发。
