豚鼠肛门内括约肌中的嘌呤受体。
Purine receptors in the guinea-pig internal anal sphincter.
作者信息
Crema A, Frigo G M, Lecchini S, Manzo L, Onori L, Tonini M
出版信息
Br J Pharmacol. 1983 Mar;78(3):599-603. doi: 10.1111/j.1476-5381.1983.tb08820.x.
Abstract
1 In the isolated internal anal sphincter of the guinea-pig, adenosine 5'-triphosphate (ATP) and adenosine induced a concentration-dependent and tetrodotoxin-insensitive relaxation. 2 Pretreatment with theophylline (25-50 microM) had no significant effect on the concentration-response curves obtained with either purine compound. 3 Reactive blue 2 (25-100 microM) shifted the curve to ATP to the right in a dose-dependent fashion leaving that to adenosine unaltered. The antagonism appeared to be non-competitive. 4 Neither reactive blue 2 nor purine receptor occupation by ATP or adenosine altered the electrically-induced non-adrenergic, non-cholinergic inhibitory response. 5 The actions of ATP and adenosine in the guinea-pig internal anal sphincter appear to be mediated by separate receptors. These receptors are not involved in the nerve-mediated relaxation.
摘要
1 在豚鼠离体的肛门内括约肌中，5'-三磷酸腺苷（ATP）和腺苷可引起浓度依赖性且对河豚毒素不敏感的舒张反应。2 用茶碱（25 - 50微摩尔）预处理对两种嘌呤化合物所得到的浓度-反应曲线均无显著影响。3 活性蓝2（25 - 100微摩尔）以剂量依赖性方式使ATP的曲线右移，而腺苷的曲线未改变。这种拮抗作用似乎是非竞争性的。4 活性蓝2以及ATP或腺苷对嘌呤受体的占据均未改变电诱导的非肾上腺素能、非胆碱能抑制反应。5 ATP和腺苷在豚鼠肛门内括约肌中的作用似乎是由不同的受体介导的。这些受体不参与神经介导的舒张反应。
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本文引用的文献
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Inhibition of fundic strips from guinea-pig stomach: the effect of theophylline on responses to adenosine, ATP and intramural nerve stimulation.豚鼠胃底条的抑制作用：茶碱对腺苷、ATP及壁内神经刺激反应的影响
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