Ishikawa Y, Takahashi T, Yamamura T
Digestion. 1983;27(4):234-8. doi: 10.1159/000198958.
Adenosine-5'-triphosphate (ATP) produced the rapid relaxation followed by the contraction in the gallbladder strips from guinea pig. The contractile response to ATP was antagonized with theophylline, but not with apamin and atropine. The dose-response curve for ATP-induced contraction was shifted to the right by theophylline. The relaxation induced by ATP was blocked by apamin, but not by theophylline, phentolamine and propranolol. The dose-response curve for ATP-induced relaxation was shifted to the right and downwards by apamin. These results indicate that two kinds of receptors for ATP exist in the guinea pig gallbladder and the theophylline-sensitive receptors may be involved in the contractile response and the apamin-sensitive receptors in relaxation.
腺苷 - 5'-三磷酸（ATP）可使豚鼠胆囊条先快速舒张，随后收缩。ATP引起的收缩反应可被茶碱拮抗，但不受蜂毒明肽和阿托品的影响。茶碱使ATP诱导收缩的剂量 - 反应曲线右移。ATP诱导的舒张被蜂毒明肽阻断，但不受茶碱、酚妥拉明和普萘洛尔的影响。蜂毒明肽使ATP诱导舒张的剂量 - 反应曲线右移并下移。这些结果表明豚鼠胆囊中存在两种ATP受体，茶碱敏感的受体可能参与收缩反应，而蜂毒明肽敏感的受体参与舒张反应。
