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蜂毒明肽,一种平滑肌松弛剂的非特异性拮抗剂。

Apamin, a nonspecific antagonist of smooth muscle relaxants.

作者信息

Muller M J, Baer H P

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1980 Feb;311(1):105-7. doi: 10.1007/BF00500310.

DOI:10.1007/BF00500310
PMID:7366739
Abstract

Apamin, a peptide of bee venom, was shown to inhibit the relaxant responses of guinea-pig taenia caeci to ATP, noradrenaline, adenosine and, less effectively, to stimulation of noradrenergic inhibitory nerves. Thus apamin acts nonspecifically and, contrary to the suggestion of Vladimirova and Shuba (1978), the fact that inhibitory responses due to nerve stimulation and ATP are blocked by the toxin does not allow conclusions as to the possible transmitter role of ATP in these nerves.

摘要

蜂毒肽是一种蜂毒中的肽,已证明它能抑制豚鼠盲肠带对ATP、去甲肾上腺素、腺苷的舒张反应,对去甲肾上腺素能抑制神经刺激的反应抑制作用较弱。因此,蜂毒肽的作用是非特异性的,与弗拉迪米罗娃和舒巴(1978年)的观点相反,神经刺激和ATP引起的抑制反应被该毒素阻断这一事实,并不足以得出关于ATP在这些神经中可能的递质作用的结论。

相似文献

1
Apamin, a nonspecific antagonist of smooth muscle relaxants.蜂毒明肽,一种平滑肌松弛剂的非特异性拮抗剂。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Feb;311(1):105-7. doi: 10.1007/BF00500310.
2
Apamin and nonadrenergic inhibition of guinea pig trachealis.蜂毒明肽与豚鼠气管的非肾上腺素能抑制作用
Agents Actions. 1987 Oct;22(1-2):75-81. doi: 10.1007/BF01968820.
3
The effects of apamin on responses evoked by field stimulation in guinea-pig taenia caeci.蜂毒明肽对豚鼠盲肠带肌条场刺激诱发反应的影响。
Eur J Pharmacol. 1981 Jul 17;73(1):1-9. doi: 10.1016/0014-2999(81)90139-4.
4
Glibenclamide and procaine, but not apamin, inhibit the relaxant responses to Ro 31-6930 in guinea-pig taenia caeci.格列本脲和普鲁卡因可抑制豚鼠盲肠带对Ro 31-6930的舒张反应,但蜂毒明肽无此作用。
Br J Pharmacol. 1989 Dec;98 Suppl:808P.
5
Effect of apamin on responses to BRL 34915, nicorandil and other relaxants in the guinea-pig taenia caeci.蜂毒明肽对豚鼠盲肠带对BRL 34915、尼可地尔及其他舒张剂反应的影响
Br J Pharmacol. 1986 May;88(1):113-20. doi: 10.1111/j.1476-5381.1986.tb09477.x.
6
The action of apamin on guinea-pig taenia caeci.蜂毒明肽对豚鼠盲肠绦虫的作用。
Eur J Pharmacol. 1980 Oct 17;67(2-3):265-74. doi: 10.1016/0014-2999(80)90507-5.
7
Effect of apamin and theophylline on adenosine-5'-triphosphate-induced response of the guinea pig gallbladder.蜂毒明肽和茶碱对豚鼠胆囊中三磷酸腺苷诱导反应的影响。
Digestion. 1983;27(4):234-8. doi: 10.1159/000198958.
8
The effect of apamin on the smooth muscle cells of the guinea-pig taenia coli.蜂毒明肽对豚鼠结肠带平滑肌细胞的作用。
Eur J Pharmacol. 1979 Sep 15;58(2):151-6. doi: 10.1016/0014-2999(79)90006-2.
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[Effect of apamin on the synaptic transmission and inhibitory activity of ATP and noradrenaline in the smooth muscle cells of the guinea pig colon].蜂毒明肽对豚鼠结肠平滑肌细胞突触传递及ATP和去甲肾上腺素抑制活性的影响
Fiziol Zh (1978). 1983 Mar-Apr;29(2):181-5.
10
Apamin distinguishes two types of relaxation mediated by enteric nerves in the guinea-pig gastrointestinal tract.蜂毒明肽区分了豚鼠胃肠道中由肠神经介导的两种松弛类型。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Jan;332(1):79-88. doi: 10.1007/BF00633202.

引用本文的文献

1
The effect of apamin on non-adrenergic, non-cholinergic vasodilator mechanisms in the intestines of the cat.蜂毒明肽对猫肠道非肾上腺素能、非胆碱能血管舒张机制的作用。
J Physiol. 1983 May;338:207-19. doi: 10.1113/jphysiol.1983.sp014669.
2
Neither a purine nor VIP is the mediator of inhibitory nerves of opossum oesophageal smooth muscle.嘌呤和血管活性肠肽都不是负鼠食管平滑肌抑制性神经的介质。
J Physiol. 1983 Mar;336:243-60. doi: 10.1113/jphysiol.1983.sp014579.
3
Purine receptors in the guinea-pig internal anal sphincter.豚鼠肛门内括约肌中的嘌呤受体。

本文引用的文献

1
[Sequence analysis of bee venom neurotoxin (apamine) from its tryptic and chymotryptic cleavage products].
Hoppe Seylers Z Physiol Chem. 1967 Jun;348(6):737-8.
2
Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut.有证据表明三磷酸腺苷或一种相关核苷酸是肠道中非肾上腺素能抑制性神经释放的递质物质。
Br J Pharmacol. 1970 Dec;40(4):668-88. doi: 10.1111/j.1476-5381.1970.tb10646.x.
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Transport of nucleosides.
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Br J Pharmacol. 1983 Mar;78(3):599-603. doi: 10.1111/j.1476-5381.1983.tb08820.x.
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Effects of quinine and apamin on the calcium-dependent potassium permeability of mammalian hepatocytes and red cells.奎宁和蜂毒明肽对哺乳动物肝细胞及红细胞钙依赖性钾通透性的影响。
J Physiol. 1981 Aug;317:67-90. doi: 10.1113/jphysiol.1981.sp013814.
5
Non-cholinergic excitatory and inhibitory junction potentials in the circular smooth muscle of the guinea-pig ileum.豚鼠回肠环形平滑肌中的非胆碱能兴奋性和抑制性接头电位。
J Physiol. 1986 May;374:153-64. doi: 10.1113/jphysiol.1986.sp016072.
6
Apamin and nonadrenergic inhibition of guinea pig trachealis.蜂毒明肽与豚鼠气管的非肾上腺素能抑制作用
Agents Actions. 1987 Oct;22(1-2):75-81. doi: 10.1007/BF01968820.
Identification of separate receptors for adenosine and adenosine 5'-triphosphate in causing relaxations of the isolated taenia of the guinea-pig caecum.腺苷和5'-三磷酸腺苷在引起豚鼠盲肠离体带状肌松弛中各自受体的鉴定。
Br J Pharmacol. 1976 Jun;57(2):305-10. doi: 10.1111/j.1476-5381.1976.tb07480.x.
5
Effect of dipyridamole and 6-(2-hydroxy-5-nitro)-benzylthioguanosine on low-frequency-stimulated relaxation in the guinea pig taenia coli.双嘧达莫和6-(2-羟基-5-硝基)-苄基硫代鸟苷对豚鼠结肠带低频刺激舒张的影响。
Can J Physiol Pharmacol. 1977 Jun;55(3):394-8. doi: 10.1139/y77-056.
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[Effect of strychnine, hydrastine and apamin on synaptic transmission in smooth muscle cells].
Neirofiziologiia. 1978;10(3):295-9.
7
The effect of apamin on the smooth muscle cells of the guinea-pig taenia coli.蜂毒明肽对豚鼠结肠带平滑肌细胞的作用。
Eur J Pharmacol. 1979 Sep 15;58(2):151-6. doi: 10.1016/0014-2999(79)90006-2.