Fukuda O, Miyamura S, Inoue S, Maeyama M
Jpn J Antibiot. 1984 Dec;37(12):2416-9.
Fundamental study on tissue distribution of ceftriaxone (Ro 13-9904, CTRX), a new cephalosporin parenteral antibiotic, was studied and the following results were obtained. CTRX had been administered by intravenous drip infusion with 1 g to 9 cases who received simple total hysterectomy. The level of CTRX in the cubital venous serum and uterine arterial serum was determined as well as the tissue concentration in the oviduct, ovary, endometrium, myometrium, cervix uteri and portio vaginalis. The level in the oviduct and portio vaginalis was generally high, although it was observed only in a few cases. The variation of the level in the myometrium was large. CTRX is expected to be clinically useful considering the fact that its half-life time is 8.5 hours, which is longer than that of existing cephalosporin antibiotics.
对新型头孢菌素类肠外抗生素头孢曲松（Ro 13 - 9904，CTRX）的组织分布进行了基础研究，并获得了以下结果。对9例行单纯全子宫切除术的患者静脉滴注1g头孢曲松。测定了肘静脉血清和子宫动脉血清中头孢曲松的水平，以及输卵管、卵巢、子宫内膜、子宫肌层、子宫颈和阴道部的组织浓度。输卵管和阴道部的浓度一般较高，不过仅在少数病例中观察到。子宫肌层中浓度的变化较大。考虑到其半衰期为8.5小时，比现有头孢菌素类抗生素的半衰期长，预计头孢曲松在临床上会有用。
