Satoh T, Mure K, Shimizu T
Jpn J Antibiot. 1984 Dec;37(12):2298-303.
Ceftriaxone (CTRX), a new cephalosporin antibiotic, was evaluated in the field of obstetrics and gynecology and the following results were obtained. The concentration of CTRX after an intravenous injection with 1 g was determined in the uterine artery, cubital vein and in the intrapelvic genital tissues such as the oviduct, ovary, endometrium, myometrium, cervix uteri and portio vaginalis. The peak level was 160 micrograms/ml at 26 minutes after injection both in the uterine arterial serum and cubital venous serum, 48 and 38 micrograms/g at 1 hour and 18 minutes in the tissues of oviduct and ovary, respectively, 54 and 50 micrograms/g at 48 minutes in the myometrium and cervix uteri, respectively, while 46 micrograms/g at 39 minutes in the portio vaginalis. The mean level 18 to 24 hours after administration was 19 micrograms/ml in the uterine arterial serum and cubital venous serum and 6.3 micrograms/g in the intrapelvic genital tissues. A case of intrapelvic infection clinically showed an excellent response without any side effects by intravenous drip infusion with 2 g divided as twice a day for 7 days. The above results show that CTRX is useful in the field of obstetrics. and gynecology.
头孢曲松（CTRX）是一种新型头孢菌素抗生素，在妇产科领域进行了评估，获得了以下结果。静脉注射1克后，测定了子宫动脉、肘静脉以及盆腔内生殖组织如输卵管、卵巢、子宫内膜、子宫肌层、子宫颈和阴道部中的CTRX浓度。注射后26分钟，子宫动脉血清和肘静脉血清中的峰值水平均为160微克/毫升，输卵管和卵巢组织在1小时18分钟时分别为48和38微克/克，子宫肌层和子宫颈在48分钟时分别为54和50微克/克，而阴道部在39分钟时为46微克/克。给药后18至24小时，子宫动脉血清和肘静脉血清中的平均水平为19微克/毫升，盆腔内生殖组织中的平均水平为6.3微克/克。1例盆腔感染患者通过每天分两次静脉滴注2克，持续7天，临床显示出良好的反应，且无任何副作用。上述结果表明CTRX在妇产科领域有用。
