Sakakura K, Hayashi S
Jpn J Antibiot. 1984 Dec;37(12):2328-37.
Fundamental and clinical studies on ceftriaxone (CTRX, Ro 13-9904) were performed in the field of obstetrics and gynecology and the following results were obtained. The serum concentration was maintained at a high level to remain 22 micrograms/ml about 24 hours after intravenous injection with 1 g CTRX. The level in each tissue except myometrium reached a peak of 50 micrograms/g or higher at 54 minutes after intravenous injection with 1 g CTRX. The peak level in the dead space exudate, obtained 4 to 6 hours after intravenous injection was 77 micrograms/ml with 1 g, and 125 micrograms/ml and 115 micrograms/ml with 2 g. The clinical efficacy was observed in all the cases (excellent in 1 and good in 3) consisting of 1 with Bartholin's abscess, 2 with adnexitis and 1 with pelvioperitonitis. Neither adverse reaction nor posttreatment laboratory test abnormality was observed in any case.
在妇产科领域开展了头孢曲松（CTRX，Ro 13 - 9904）的基础及临床研究，并取得了以下结果。静脉注射1g CTRX后约24小时，血清浓度维持在较高水平，约为22微克/毫升。静脉注射1g CTRX后54分钟，除子宫肌层外的各组织中的浓度达到50微克/克或更高的峰值。静脉注射1g后4至6小时获得的死腔渗出液中的峰值浓度为77微克/毫升，注射2g时为125微克/毫升和115微克/毫升。在所有病例中均观察到临床疗效（1例为优，3例为良），这些病例包括1例巴氏腺脓肿、2例附件炎和1例盆腔腹膜炎。在任何病例中均未观察到不良反应或治疗后实验室检查异常。
